Brouwer, Rachel MKlein, MariekeGrasby, Katrina LSchnack, Hugo GJahanshad, NedaTeeuw, JalmarThomopoulos, Sophia ISprooten, EmmaFranz, Carol EGogtay, NitinKremen, William SPanizzon, Matthew SOlde Loohuis, Loes MWhelan, Christopher DAghajani, MojiAlloza, ClaraAlnæs, DagArtiges, EricAyesa-Arriola, RosaBarker, Gareth JBastin, Mark EBlok, ElisabetBøen, ErlendBreukelaar, Isabella ABright, Joanna KBuimer, Elizabeth E LBülow, RobinCannon, Dara MCiufolini, SimoneCrossley, Nicolas ADamatac, Christienne GDazzan, Paolade Mol, Casper Lde Zwarte, Sonja M CDesrivières, SylvaneDíaz-Caneja, Covadonga MDoan, Nhat TrungDohm, KatharinaFröhner, Juliane HGoltermann, JanikGrigis, AntoineGrotegerd, DominikHan, Laura K MHarris, Mathew AHartman, Catharina AHeany, Sarah JHeindel, WalterHeslenfeld, Dirk JHohmann, SarahIttermann, BerndJansen, Philip RJanssen, JoostJia, TianyeJiang, JiyangJockwitz, ChristianeKarali, TemmuzKeeser, DanielKoevoets, Martijn G J CLenroot, Rhoshel KMalchow, BerendMandl, René C WMedel, VicenteMeinert, SusanneMorgan, Catherine AMühleisen, Thomas WNabulsi, LeilaOpel, Nilsde la Foz, Víctor Ortiz-GarcíaOvers, Bronwyn JPaillère Martinot, Marie-LaureRedlich, RonnyMarques, Tiago ReisRepple, JonathanRoberts, GloriaRoshchupkin, Gennady VSetiaman, NikitaShumskaya, ElenaStein, FrederikeSudre, GustavoTakahashi, ShunThalamuthu, AnbupalamTordesillas-Gutiérrez, Dianavan der Lugt, Aadvan Haren, Neeltje E MWardlaw, Joanna MWen, WeiWesteneng, Henk-JanWittfeld, KatharinaZhu, Alyssa HZugman, AndreArmstrong, Nicola JBonfiglio, GaiaBralten, JanitaDalvie, ShareefaDavies, GailDi Forti, MartaDing, LindaDonohoe, GaryForstner, Andreas JGonzalez-Peñas, JavierGuimaraes, Joao P O F THomuth, GeorgHottenga, Jouke-JanKnol, Maria JKwok, John B JLe Hellard, StephanieMather, Karen AMilaneschi, YuriMorris, Derek WNöthen, Markus MPapiol, SergiRietschel, MarcellaSantoro, Marcos LSteen, Vidar MStein, Jason LStreit, FabianTankard, Rick MTeumer, Alexandervan 't Ent, Dennisvan der Meer, Dennisvan Eijk, Kristel RVassos, EvangelosVázquez-Bourgon, JavierWitt, Stephanie HIMAGEN ConsortiumAdams, Hieab H HAgartz, IngridAmes, DavidAmunts, KatrinAndreassen, Ole AArango, CelsoBanaschewski, TobiasBaune, Bernhard TBelangero, Sintia IBokde, Arun L WBoomsma, Dorret IBressan, Rodrigo ABrodaty, HenryBuitelaar, Jan KCahn, WiepkeCaspers, SvenjaCichon, SvenCrespo-Facorro, BenedictoCox, Simon RDannlowski, UdoElvsåshagen, TorbjørnEspeseth, ThomasFalkai, Peter GFisher, Simon EFlor, HertaFullerton, Janice MGaravan, HughGowland, Penny AGrabe, Hans JHahn, TimHeinz, AndreasHillegers, ManonHoare, JacquelineHoekstra, Pieter JIkram, Mohammad AJackowski, Andrea PJansen, AndreasJönsson, Erik GKahn, Rene SKircher, TiloKorgaonkar, Mayuresh SKrug, AxelLemaitre, HerveMalt, Ulrik FMartinot, Jean-LucMcDonald, ColmMitchell, Philip BMuetzel, Ryan LMurray, Robin MNees, FraukeNenadić, IgorOosterlaan, JaapOphoff, Roel APan, Pedro MPenninx, Brenda W J HPoustka, LuiseSachdev, Perminder SSalum, Giovanni ASchofield, Peter RSchumann, GunterShaw, PhilipSim, KangSmolka, Michael NStein, Dan JTrollor, Julian Nvan den Berg, Leonard HVeldink, Jan HWalter, HenrikWestlye, Lars TWhelan, RobertWhite, TonyaWright, Margaret JMedland, Sarah EFranke, BarbaraThompson, Paul MHulshoff Pol, Hilleke E2023-05-032023-05-032022-04-05http://hdl.handle.net/10668/19576Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.enAgingBrainGenome-Wide Association StudyHumansLongevityMagnetic Resonance Imagingresearch article35383335open access10.1038/s41593-022-01042-41546-1726PMC10040206https://pure.rug.nl/ws/files/213351503/s41593_022_01042_4.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040206/pdf