Dominguez-Tellez, PabloMoral-Muñoz, Jose ASalazar, AlejandroCasado-Fernandez, EstebanLucena-Anton, David2023-02-082023-02-082020Domínguez-Téllez P, Moral-Muñoz JA, Salazar A, Casado-Fernández E, Lucena-Antón D. Game-Based Virtual Reality Interventions to Improve Upper Limb Motor Function and Quality of Life After Stroke: Systematic Review and Meta-analysis. Games Health J. 2020 Feb;9(1):1-10http://hdl.handle.net/10668/15058Stroke is the main cause of disability in adulthood. Recent advances in virtual reality (VR) technologies have led to its increased use in the rehabilitation of stroke patients. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effectiveness of game-based reality on upper limb (UL) motor function and quality of life after stroke. In March 2018, a search of the following databases was performed: PubMed, PEDro, Web of Science, Scopus, The Cochrane Library, and Medline at EBSCO. The selection criteria were all RCTs published in English or Spanish during the past 10 years. The PEDro scale was used to evaluate the methodological quality of the studies. A total of 20 clinical trials were included in the systemic review, of which 15 contributed information to the meta-analysis. Favorable results were found for VR interventions on UL motor function (Fugl-Meyer Assessment for upper extremity, standardized mean difference [SMD] = 1.53, 95% CI [0.51-2.54]) and quality of life (functional independence measure, SMD = 0.77, 95% CI [0.05-1.49]). The results demonstrate the potential benefits of VR interventions on the recovery of UL motor function and on quality of life after stroke.enMeta-analysisPhysical therapyStrokeVirtual realityActivities of daily livingHumansQuality of lifeRandomized controlled trials as topicRecovery of functionStrokeStroke rehabilitationUpper extremityVideo gamesVirtual realityresearch article32027185open accessAccidente cerebrovascularActividades cotidianasCalidad de vidaExtremidad superiorJuegos de videoRealidad virtualRecuperación de la funciónRehabilitación de accidente cerebrovascular10.1089/g4h.2019.00432161-7856https://www.liebertpub.com/doi/pdf/10.1089/g4h.2019.0043