Lalueza, AAyuso, BArrieta, ETrujillo, HFolgueira, DCueto, CSerrano, ALaureiro, JArévalo-Cañas, CCastillo, CDíaz-Pedroche, CLumbreras, CINFLUDOC group2025-01-072025-01-072020-02-28https://hdl.handle.net/10668/25349There is increasing evidence that ferritin is a key marker of macrophage activation, but its potential role in influenza infection remains unexplored. Our aim was to assess whether hyperferritinaemia (ferritin ≥500 ng/mL) could be a marker of poor prognosis in hospitalized patients with confirmed influenza A infection. We prospectively recruited all hospitalized adult patients who tested positive for the influenza A rRT-PCR assay performed on respiratory samples in two consecutive influenza periods (2016-17 and 2017-18). Poor outcome was defined as the presence of at least one of the following: respiratory failure, admission to the intensive care unit, or in-hospital mortality. Among 494 patients, 68 (14%) developed poor outcomes; 112 patients (23%) had hyperferritinaemia (39/68, 57% in the poor-outcome group versus 73/426, 17% in the remaining patients, p  Serum ferritin may discriminate a subgroup of patients with influenza infection who have a higher risk of developing a poor outcome.enFerritinHyperferritinaemiaInfluenzaOutcomeRespiratory failureAgedAged, 80 and overCritical CareFemaleFerritinsHospital MortalityHospitalizationHumansInfluenza A virusInfluenza, HumanMaleMiddle AgedPrognosisProspective StudiesRespiratory InsufficiencyUp-Regulationresearch article32120038open access10.1016/j.cmi.2020.02.0181469-0691http://www.clinicalmicrobiologyandinfection.com/article/S1198743X20301002/pdf