Crujeiras, Ana BDiaz-Lagares, AngelStefansson, Olafur AMacias-Gonzalez, ManuelSandoval, JuanCueva, JuanLopez-Lopez, RafaelMoran, SebastianJonasson, Jon GTryggvadottir, LaufeyOlafsdottir, ElinborgTinahones, Francisco JCarreira, Marcos CCasanueva, Felipe FEsteller, Manel2025-01-072025-01-072017-04-25https://hdl.handle.net/10668/26289Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with information on BMI and menopausal status. Additionally, DNA methylation results were validated in 18 non-tumor and 81 tumor breast samples. Breast tumors arising in either pre- or postmenopausal women stratified by BMI or menopausal status alone were not associated with a specific DNA methylation pattern. Intriguingly, the DNA methylation pattern identified in association with the high-risk group (postmenopausal women with high BMI (>25) and premenopausal women with normal or low BMI 25) and premenopausal women with normal or low BMI en450k methylation arrayDNA methylationbreast cancerepigenomicsobesityBreast NeoplasmsCohort StudiesDNA MethylationEpigenomicsFemaleHumansMenopauseMiddle AgedObesityresearch article28442560open access10.1530/ERC-16-05651479-6821https://erc.bioscientifica.com/downloadpdf/journals/erc/24/7/351.pdf