Yazdani, RHabibi, SSharifi, LAzizi, GAbolhassani, HOlbrich, PAghamohammadi, A2023-01-252023-01-252019-02-11Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, et al. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management. J Investig Allergol Clin Immunol. 2020;30(1):14-34.1018-9068http://hdl.handle.net/10668/13543Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency, with a wide variety of infectious and noninfectious complications. Numerous studies have demonstrated that immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss various aspects of CVID, including epidemiology, pathogenesis, symptoms, diagnosis, classification, and management.enClassificationsCommon variable immunodeficiencyDiagnosisEpidemiologyManagementPathogenesisSymptomsAgammaglobulinemiaAnimalsCommon Variable ImmunodeficiencyGene-Environment InteractionHematopoietic Stem Cell TransplantationHumansImmunoglobulins, IntravenousPhenotypeReview30741636Restricted AccessEnfermedadAgammaglobulinemiaInmunodeficiencia variable comúnClasificaciónRevisiónDiagnósticoAntecedentes genéticosInfecciones bacterianasEpidemiología10.18176/jiaci.0388http://www.jiaci.org/revistas/vol30issue1_2.pdf