Diaz, Alfonso RodriguezReina, Carlos O'ConnorPlaza, GuillermoPosadas, Elena RodriguezArevalo, Francisco ValdeonIriarte, Maria Teresa Garcia2023-02-092023-02-092020-12-14http://hdl.handle.net/10668/16788To assess clinical and functional outcomes of a fat graft myringoplasty under local in an office setting. Prospective case series. Tertiary care facility. Patients with a tympanic membrane (TM) perforation presenting between December 2005 and June 2019. Inclusion criteria included perforation size >25% of the surface of the pars tensa of the TM, entire perforation margins visualized through a transcanal view, and lack of spontaneous closure at the 6-month follow-up. The exclusion criteria were the presence of cholesteatoma, wet appearance of the mucosa in the tympanic cavity, ear discharge in the 3 months before surgery, or signs of ossicular inconsistency. In-office fat graft myringoplasty technique under local anesthesia. Complete perforation closure rate and audiometric outcomes. A total of 121 patients underwent the procedure, of whom 21 had bilateral sequential procedures (total 142 ears). Average age was 51.1 ± 18.4 years (range, 3-78 years). The size of perforation was In office fat graft myringoplasty, in adult and pediatric patients with variable perforation sizes, is a well-tolerated procedure with very satisfactory clinical results.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/fat grafthearing lossmiddle ear surgeryoffice surgerytympanoplastyAdipose TissueAdultAmbulatory Surgical ProceduresFemaleFollow-Up StudiesHumansMaleMiddle AgedMyringoplastyNeckProspective StudiesTreatment OutcomeTympanic MembraneTympanic Membrane Perforationresearch article33314958open access10.1177/01455613209735551942-7522https://journals.sagepub.com/doi/pdf/10.1177/0145561320973555