O'Valle, Franciscode Buitrago, Juan GHernández-Cortés, PedroPadial-Molina, MiguelCrespo-Lora, VicenteCobo, MarienAguilar, DavidGalindo-Moreno, Pablo2023-01-252023-01-252018-08-16http://hdl.handle.net/10668/12845This study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after maxillary sinus grafting procedures. Musashi-1 was analyzed by immunohistochemistry and RT-PCR. MSI1 was detected in osteoblasts and osteocytes in 97.4% (38/39) of grafted areas. In native bone, MSI1 was detected in only 66.6% (12/18) of the biopsies, mainly in osteocytes. Detection of MSI1 was significantly higher in osteoprogenitor mesenchymal cells of grafted biopsies (p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultAgedBiopsyCell DifferentiationFemaleGene Expression RegulationHumansMaleMaxillary SinusMesenchymal Stem CellsMiddle AgedNerve Tissue ProteinsOsteoblastsOsteocytesRNA, MessengerRNA-Binding ProteinsSinus Floor Augmentationresearch article30116022open access10.1038/s41598-018-29908-32045-2322PMC6095840https://www.nature.com/articles/s41598-018-29908-3.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095840/pdf