Gunter, Marc JMurphy, NeilCross, Amanda JDossus, LaureDartois, LaureenFagherazzi, GuyKaaks, RudolfKühn, TilmanBoeing, HeinerAleksandrova, KrasimiraTjønneland, AnneOlsen, AnjaOvervad, KimLarsen, Sofus ChristianRedondo Cornejo, Maria LuisaAgudo, AntonioSanchez-Perez, Maria-JoseAltzibar, Jone MNavarro, CarmenArdanaz, EvaKhaw, Kay-TeeButterworth, AdamBradbury, Kathryn ETrichopoulou, AntoniaLagiou, PagonaTrichopoulos, DimitriosPalli, DomenicoGrioni, SaraVineis, PaoloPanico, SalvatoreTumino, RosarioBueno-de-Mesquita, BasSiersema, PeterLeenders, MaxBeulens, Joline W JUiterwaal, Cuno UWallström, PeterNilsson, Lena MariaLandberg, RikardWeiderpass, ElisabeteSkeie, GuriBraaten, TonjeBrennan, PaulLicaj, IdlirMuller, David CSinha, RashmiWareham, NickRiboli, Elio2023-01-252023-01-252017-07-11http://hdl.handle.net/10668/11389The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Prospective cohort study. 10 European countries. 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend  Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country. European Commission Directorate-General for Health and Consumers and International Agency for Research on Cancer.enAdultBiomarkersCardiovascular DiseasesCause of DeathCerebrovascular DisordersCoffeeDigestive System DiseasesDrinkingEuropeFemaleHumansInflammationLiver Function TestsMaleMiddle AgedMortalityOvarian NeoplasmsProportional Hazards ModelsProspective StudiesRisk Factorsresearch article28693038open access10.7326/M16-29451539-3704PMC5788283https://europepmc.org/articles/pmc5788283?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788283/pdf