Romero-Gonzalez, MarinaNavas-Sanchez, PatriciaMarin-Gamez, EsterBarbancho-Fernandez, Miguel AngelFernandez-Sanchez, Victoria EugeniaLara-Muñoz, Jose PabloGuzman-Parra, Jose2023-05-032023-05-032022-03-15Romero-González M, Navas-Sánchez P, Marín-Gámez E, Barbancho-Fernández MA, Fernández-Sánchez VE, Lara-Muñoz JP, et al. EEG abnormalities and clinical phenotypes in pre-school children with autism spectrum disorder. Epilepsy Behav. 2022 Apr;129:108619http://hdl.handle.net/10668/22545Abnormalities on electroencephalography (EEG) results have been reported in a high percentage of children with Autism Spectrum Disorder (ASD). The purpose of this study was to explore the prevalence of EEG abnormalities in a clinical population of pre-school children with Autism Spectrum Disorder and the differences in terms of the following phenotypic characteristics: adaptive behavior, executive functioning, severity of Autism Spectrum Disorder core symptoms, and comorbidity symptoms. A cross-sectional analysis of 69 children who attended the Autism Spectrum Disorder early diagnosis program with electroencephalography and clinical diagnosis was performed. A battery of questionnaires was also made to parents to evaluate emotions, behavior, and functional skills for daily living. Out of 69 pre-school children with Autism Spectrum Disorder, twenty nine (42%) had abnormalities in electroencephalography results. The group with abnormal epileptiform electroencephalography exhibited more impairment in executive functioning and social-relationship coexisting symptoms. The presence of an abnormal epileptiform electroencephalography in pre-school children with ASD already suggests a worse development in clinical features.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Autism spectrum disorderClinical featuresEEG abnormalitiesPre-school childrenAutism Spectrum DisorderChildChild, PreschoolCross-Sectional StudiesElectroencephalographyExecutive FunctionHumansPhenotyperesearch article35303620open accessElectroencefalografíaTrastorno del Espectro AutistaInstituciones AcadémicasAdaptación PsicológicaPadres10.1016/j.yebeh.2022.1086191525-5069http://www.epilepsybehavior.com/article/S1525505022000683/pdf