Priya Doss, C GeorgeAlasmar, Dima RBux, Reem ISneha, PBakhsh, Fadheela DadAl-Azwani, ImanBekay, Rajaa ElZayed, Hatem2016-12-072016-12-072016-11-17Doss CG, Alasmar DR, Bux RI, Sneha P, Bakhsh FD, Al-Azwani I, et al. Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World. Sci Rep. 2016 ; 6:37284http://hdl.handle.net/10668/2560Journal Article;A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) in the 22 Arab countries. Our search yielded 43 studies that captured 33 mutations (23 missense, one silent, two deletions, and seven intronic mutations), in 3,430 Arab patients with G6PDD. The 23 missense mutations were then subjected to phenotypic classification using in silico prediction tools, which were compared to the WHO pathogenicity scale as a reference. These in silico tools were tested for their predicting efficiency using rigorous statistical analyses. Of the 23 missense mutations, p.S188F, p.I48T, p.N126D, and p.V68M, were identified as the most common mutations among Arab populations, but were not unique to the Arab world, interestingly, our search strategy found four other mutations (p.N135T, p.S179N, p.R246L, and p.Q307P) that are unique to Arabs. These mutations were exposed to structural analysis and molecular dynamics simulation analysis (MDSA), which predicting these mutant forms as potentially affect the enzyme function. The combination of the MDSA, structural analysis, and in silico predictions and statistical tools we used will provide a platform for future prediction accuracy for the pathogenicity of genetic mutations.enMundo árabeÁrabesGlucosafosfato deshidrogenasaDeficiencia de glucosafosfato deshidrogenasHumansMedio orienteSimulación de dinámica molecularMutaciónMutación missensePubMedEliminación de secuenciaVirulenciaMedical Subject Headings::Disciplines and Occupations::Social Sciences::Anthropology::Anthropology, Cultural::Culture::Civilization::Arab WorldMedical Subject Headings::Named Groups::Persons::Population Groups::Ethnic Groups::ArabsMedical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Metabolism, Inborn Errors::Carbohydrate Metabolism, Inborn Errors::Glucosephosphate Dehydrogenase DeficiencyMedical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Metabolism, Inborn Errors::Carbohydrate Metabolism, Inborn Errors::Glucosephosphate Dehydrogenase DeficiencyMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Geographicals::Geographic Locations::Historical Geographic Locations::Middle EastMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Molecular Structure::Molecular Dynamics SimulationMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::MutationMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Mutation, MissenseMedical Subject Headings::Information Science::Information Science::Medical Informatics::Medical Informatics Applications::Information Systems::Online Systems::PubMedMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Sequence DeletionMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Virulenceresearch article27853304open access10.1038/srep372842045-2322