Roy, AlvaroTomé, IreneRomero, BeatrizLorente-Leal, VíctorInfantes-Lorenzo, José ADomínguez, MercedesMartín, CarlosAguiló, NachoPuentes, EugeniaRodríguez, Estebande Juan, LucíaRisalde, María AGortázar, ChristianDomínguez, LucasBezos, Javier2020-07-242020-07-242019-10-15Roy A, Tomé I, Romero B, Lorente-Leal V, Infantes-Lorenzo JA, Domínguez M, et al. Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis. Vet Res. 2019 Oct 15;50:82.0928-4249http://hdl.handle.net/10668/3149Effective vaccines against tuberculosis (TB) are needed in order to prevent TB transmission in human and animal populations. Evaluation of TB vaccines may be facilitated by using reliable animal models that mimic host pathophysiology and natural transmission of the disease as closely as possible. In this study, we evaluated the immunogenicity and efficacy of two attenuated vaccines, BCG and MTBVAC, after each was given to 17 goats (2 months old) and then exposed for 9 months to goats infected with M. caprae. In general, MTBVAC-vaccinated goats showed higher interferon-gamma release than BCG vaccinated goats in response to bovine protein purified derivative and ESAT-6/CFP-10 antigens and the response was significantly higher than that observed in the control group until challenge. All animals showed lesions consistent with TB at the end of the study. Goats that received either vaccine showed significantly lower scores for pulmonary lymph nodes and total lesions than unvaccinated controls. Both MTBVAC and BCG vaccines proved to be immunogenic and effective in reducing severity of TB pathology caused by M. caprae. Our model system of natural TB transmission may be useful for evaluating and optimizing vaccines.enBCG VaccineVacuna BCGMycobacterium tuberculosisTuberculosisMycobacterium bovisInfecciones por mycobacteriumMycobacterium infectionsBacterial vaccinesVacunas bacterianasNatural transmissionTransmisión naturalGoatsCabraAnimalsHumansMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Bacterial Vaccines::Tuberculosis Vaccines::BCG VaccineMedical Subject Headings::Diseases::Animal Diseases::Goat DiseasesMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Ruminants::GoatsMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, CellularMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, HumoralMedical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Tenericutes::Mycoplasmatales::Mycoplasmataceae::MycoplasmaMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::TuberculosisMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Bacterial Vaccines::Tuberculosis VaccinesMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Vaccines, AttenuatedMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosisresearch article31615555open access10.1186/s13567-019-0702-71297-9716PMC6792192