Boot, Iris W AWesselius, AnkeYu, Evan Y WBrinkman, Mareevan den Brandt, PietGrant, Eric JWhite, EmilyWeiderpass, ElisabeteFerrari, PietroSchulze, Matthias BBueno-de-Mesquita, BasJose-Sanchez, MariaGylling, BjornZeegers, Maurice P2023-05-032023-05-032022-01-11Boot IWA, Wesselius A, Yu EYW, Brinkman M, van den Brandt P, Grant EJ, et al. Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies. Eur J Nutr. 2022 Aug;61(5):2397-2416.http://hdl.handle.net/10668/19897Diet may play an essential role in the aetiology of bladder cancer (BC). The B group complex vitamins involve diverse biological functions that could be influential in cancer prevention. The aim of the present study was to investigate the association between various components of the B group vitamin complex and BC risk. Dietary data were pooled from four cohort studies. Food item intake was converted to daily intakes of B group vitamins and pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were obtained using Cox-regression models. Dose-response relationships were examined using a nonparametric test for trend. In total, 2915 BC cases and 530,012 non-cases were included in the analyses. The present study showed an increased BC risk for moderate intake of vitamin B1 (HRB1: 1.13, 95% CI: 1.00-1.20). In men, moderate intake of the vitamins B1, B2, energy-related vitamins and high intake of vitamin B1 were associated with an increased BC risk (HR (95% CI): 1.13 (1.02-1.26), 1.14 (1.02-1.26), 1.13 (1.02-1.26; 1.13 (1.02-1.26), respectively). In women, high intake of all vitamins and vitamin combinations, except for the entire complex, showed an inverse association (HR (95% CI): 0.80 (0.67-0.97), 0.83 (0.70-1.00); 0.77 (0.63-0.93), 0.73 (0.61-0.88), 0.82 (0.68-0.99), 0.79 (0.66-0.95), 0.80 (0.66-0.96), 0.74 (0.62-0.89), 0.76 (0.63-0.92), respectively). Dose-response analyses showed an increased BC risk for higher intake of vitamin B1 and B12. Our findings highlight the importance of future research on the food sources of B group vitamins in the context of the overall and sex-stratified diet.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/B group vitaminsBladder cancerNutritional oncologyPooled cohort analysisCohort StudiesDietFemaleHumansMaleProspective StudiesRisk FactorsThiamineUrinary Bladder NeoplasmsVitamin AVitamin B 12Vitamin B Complexresearch article35129646open accessComplejo vitamínico BDietaEstudios prospectivosEstudios de cohortesFactores de riesgoFemeninoHumanosMasculinoNeoplasias de la vejiga urinariaTiaminaVitamina AVitamina B 1210.1007/s00394-022-02805-21436-6215PMC9279207https://link.springer.com/content/pdf/10.1007/s00394-022-02805-2.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279207/pdf