Torres, AntoniMotos, AnnaCeccato, AdrianBermejo-Martin, Jesusde Gonzalo-Calvo, DavidPerez, RaquelBarroso, MartaPascual, Ion ZubizarretaGonzalez, JessicaFernandez-Barat, LaiaFerrer, RicardRiera, JordiGarcia-Gasulla, DarioPeñuelas, OscarLorente, Jose AngelAlmansa, RaquelMenendez, RosarioKiarostami, KasraCanseco, JoanVillar, Rosario AmayaAñon, Jose MMariño, Ana BalanBarbera, CarmeBarberan, JoseOrtiz, Aaron BlandinoBoado, Maria VictoriaBustamante-Munguira, ElenaCaballero, JesusCanton-Bulnes, Maria LuisaPerez, Cristina CarbajalesCarbonell, NievesCatalan-Gonzalez, Mercedesde Frutos, RaulFranco, NievesGalban, CristobalGumucio-Sanguino, Victor DTorre, Maria Del Carmen de laDiaz, EmiliEstella, AngelGallego, ElenaGarmendia, Jose Luis GarciaGomez, Jose MHuerta, ArturoGarcia, Ruth Noemi JorgeLoza-Vazquez, AnaMarin-Corral, JudithDelgado, Maria Cruz MartinMartinez de la Gandara, AmaliaVarela, Ignacio MartinezMessa, Juan LopezAlbaiceta, Guillermo MNieto, MaiteNovo, Mariana AndreaPeñasco, YhivianPerez-Garcia, FelipePozo-Laderas, Juan CarlosRicart, PilarSagredo, VictorSanchez-Miralles, AngelChinesta, Susana SanchoSerra-Fortuny, MireiaSocias, LorenzoSole-Violan, JordiSuarez-Sipmann, FernandoLomas, Luis TamayoTrenado, JoseUbeda, AlejandroValdivia, Luis JorgeVidal, PabloBarbe, Ferran2023-05-032023-05-032022-03-30Torres A, Motos A, Ceccato A, Bermejo-Martin J, de Gonzalo-Calvo D, Pérez R, et al. Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units. Arch Bronconeumol. 2022 Apr;58 Suppl 1:22-31http://hdl.handle.net/10668/22012The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call. CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality. This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients. We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs.enBiomarcadoresBiomarkersCOVID-19Data managementEstudios observacionalesFollow-upGestión de datosICUObservational studiesSeguimientoUCIÁrea de Gestión Sanitaria Campo de Gibraltar OesteÁrea de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de CádizÁrea de Gestión Sanitaria Sur de SevillaCOVID-19Critical illnessHumansIntensive care unitsMicroRNAsPandemicsProspective studiesRespiration, artificialRetrospective studiesSARS-CoV-2research article35491287open accessEnfermedad críticaMicroARNsPandemiasRespiración artificialUnidades de cuidados intensivos10.1016/j.arbres.2022.03.0101579-2129PMC9012512https://doi.org/10.1016/j.arbres.2022.03.010https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012512/pdf