Camarillo, RosaJimeno, SoniaHuertas, Pablo2022-09-212022-09-212021-10-08Camarillo R, Jimeno S, Huertas P. The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes. Front Genet. 2021 Oct 8;12:742434.http://hdl.handle.net/10668/4085The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/R-loopsDNA double strand break repairHomologous recombination (HR)DNA end resectionG-quadruplexEstructuras R-loopRecombinación homólogaG-cuádruplexADNARNMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::CuesMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Nucleic Acid Conformation::G-QuadruplexesMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Homologous RecombinationMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic AcidsMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Nucleic Acid Conformation::DNA, B-FormMedical Subject Headings::Phenomena and Processes::Biological PhenomenaMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNAMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Nucleic Acid Conformation::G-QuadruplexesMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNAresearch article34691154Acceso abierto10.3389/fgene.2021.7424341664-8021PMC8531813