Lopez-Tarruella, SaraEscudero, M JPollan, MarinaMartin, MiguelJara, CarlosBermejo, BegoñaGuerrero-Zotano, AngelGarcia-Saenz, JoseSantaballa, AnaAlba, EmilioAndres, RaquelMartinez, PurificacionCalvo, LourdesFernandez, AntonioBatista, NorbertoLlombart-Cussac, AntonioAnton, AntonioLahuerta, Ainharade la Haba, JuanLopez-Vega, Jose ManuelCarrasco, E2023-02-082023-02-082019-12-02Lopez-Tarruella S, Escudero MJ, Pollan M, Martín M, Jara C, Bermejo B, et al. Survival impact of primary tumor resection in de novo metastatic breast cancer patients (GEICAM/El Alamo Registry). Sci Rep. 2019 Dec 27;9(1):20081.http://hdl.handle.net/10668/14894The debate about surgical resection of primary tumor (PT) in de novo metastatic breast cancer (MBC) patients persists. We explored this approach's outcomes in patients included in a retrospective registry, named El Álamo, of breast cancer patients diagnosed in Spain (1990-2001). In this analysis we only included de novo MBC patients, 1415 of whom met the study's criteria. Descriptive, Kaplan-Meier and Cox regression analyses were carried out. Median age was 63.1 years, 49.2% of patients had single-organ metastasis (skin/soft tissue [16.3%], bone [33.8%], or viscera [48.3%]). PT surgery (S) was performed in 44.5% of the cases. S-group patients were younger, had smaller tumors, higher prevalence of bone and oligometastatic disease, and lower prevalence of visceral involvement. With a median follow-up of 23.3 months, overall survival (OS) was 39.6 versus 22.4 months (HR = 0.59, p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cancer epidemiologyBreast cancerAgedBreast NeoplasmsFemaleHumansMiddle AgedNeoplasm MetastasisRegistriesRetrospective StudiesSpainresearch article31882586open accessAncianoEspañaEstudios retrospectivosFemeninoHumanosMetástasis de la neoplasiaNeoplasias de la mamaPersona de mediana edadSistema de registros10.1038/s41598-019-55765-92045-2322PMC6934456https://www.nature.com/articles/s41598-019-55765-9.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934456/pdf