Schoisswohl, StefanLangguth, BertholdSchecklmann, MartinBernal-Robledano, AlbertoBoecking, BenjaminCederroth, Christopher R.Chalanouli, DimitraCima, RilanaDenys, SamDettling-Papargyris, JulianeEscalera-Balsera, AlbaEspinosa-Sanchez, Juan ManuelGallego-Martinez, AlvaroGiannopoulou, EfiHidalgo-Lopez, LeyreHummel, MichaelKikidis, DimitrisKoller, MichaelLopez-Escamez, Jose A.Marcrum, Steven C.Markatos, NikolaosMartin-Lagos, JuanMartinez-Martinez, MariaMartinez-Martinez, MartaMata Ferron, MariaMazurek, BirgitMueller-Locatelli, NicolasNeff, PatrickOppel, KevinPerez-Carpena, PatriciaRobles-Bolivar, PaulaRose, MatthiasSchiele, TabeaSchiller, AxelSimoes, JorgeStark, SabineStaudinger, SusanneStege, AlexandraVerhaert, NicolasSchlee, Winfried2022-09-122022-09-122021-12-04Schoisswohl S, Langguth B, Schecklmann M, Bernal-Robledano A, Boecking B, Cederroth CR, Chalanouli D, Cima R, Denys S, Dettling-Papargyris J, Escalera-Balsera A, Espinosa-Sanchez JM, Gallego-Martinez A, Giannopoulou E, Hidalgo-Lopez L, Hummel M, Kikidis D, Koller M, Lopez-Escamez JA, Marcrum SC, Markatos N, Martin-Lagos J, Martinez-Martinez M, Martinez-Martinez M, Ferron MM, Mazurek B, Mueller-Locatelli N, Neff P, Oppel K, Perez-Carpena P, Robles-Bolivar P, Rose M, Schiele T, Schiller A, Simoes J, Stark S, Staudinger S, Stege A, Verhaert N, Schlee W. Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial. Trials. 2021 Dec 4;22(1):875http://hdl.handle.net/10668/4032Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments, or applications of interventions targeting only a single organ level. Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization, might provide remedy and enhance treatment responses. The aim of the present study is to systematically examine established tinnitus therapies both alone and in combination in a large sample of tinnitus patients. Further, it wants to provide the basis for personalized treatment approaches by evaluating a specific decision support system developed as part of an EU-funded collaborative project (Unification of treatments and interventions for tinnitus patients; UNITI project).enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/TinnitusTreatmentHearing aidsCognitive behavioral therapySound therapyStructured counselingMulti-centerRCTAcúfenoTerapéuticaAudífonosTerapia cognitivo-conductualTerapia de sonidosEnsayos clínicos controlados no aleatorios como asuntoConsejoMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychology, Applied::CounselingMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Multicenter Studies as TopicMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as TopicMedical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychotherapy::Behavior Therapy::Cognitive TherapyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Sensory Aids::Hearing AidsMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Tinnitusresearch article34863270open access10.1186/s13063-021-05835-z1745-6215PMC8642746