Lopez-Cano, CarolinaCiudin, AndreeaSanchez, EnricTinahones, Francisco JBarbe, FerranDalmases, MireiaGarcia-Ramirez, MartaSoto, AlfonsoGaeta, Anna MichelaPellitero, SilviaMarti, RaquelHernandez, CristinaSimo, RafaelLecube, Albert2023-05-032023-05-032022-11-01López-Cano C, Ciudin A, Sánchez E, Tinahones FJ, Barbé F, Dalmases M, et al. Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study. Diabetes. 2022 Feb 1;71(2):315-320http://hdl.handle.net/10668/20499To evaluate the effect of liraglutide, a glucagon-like peptide 1 receptor agonist, on pulmonary function and serum levels of surfactant protein D (SP-D) in type 2 diabetes. A double-blind, randomized, crossover, placebo-controlled clinical trial comprising 76 patients with a baseline forced expiratory volume in 1 s<90% of that predicted. Liraglutide was administered for 7 weeks (2 weeks of titration plus 5 weeks at 1.8 mg daily). This short duration was intentional to minimize weight loss as a potential confounding factor. Serum level of SP-D was used as a biomarker of alveolar-capillary barrier integrity. Liraglutide exerted a positive impact on forced vital capacity (FVC) in comparison with placebo (DFVC 5.2% of predicted [from 0.8 to 9.6]; P 5 0.009). No differences in the other pulmonary variables were observed. Participants under liraglutide treatment also experienced a decrease in serum SP-D (P 5 0.038). The absolute change in FVC correlated with final serum SP-D in participants receiving liraglutide (r 5 20.313, P 5 0.036). Stepwise multivariate regression analysis showed that f inal serum SP-D independently predicted changes in FVC. In conclusion, liraglutide increased FVC in patients with type 2 diabetes. This effect was associated with a significant decrease of circulating SP-D, thus pointing to abeneficial effect in the alveolar-capillary function.enAgedBlood GlucoseCross-Over StudiesDiabetes Mellitus, Type 2Double-Blind MethodFemaleGlycemic ControlHumansLiraglutideLungMaleMiddle AgedPulmonary Surfactant-Associated Protein DSpainVital CapacityLiraglutidePulmonary Surfactant-Associated Protein DDiabetes Mellitus, Type 2Forced Expiratory VolumeVital Capacityresearch article34737187Restricted AccessCapilaresDiabetes Mellitus tipo 2Pérdida de pesoBiomarcadoresVolumen espiratorio forzado10.2337/db21-06881939-327Xhttps://diabetesjournals.org/diabetes/article-pdf/71/2/315/640899/db210688.pdf