Tan, M YPoon, L CRolnik, D LSyngelaki, Ade Paco Matallana, CAkolekar, RCicero, SJanga, DSingh, MMolina, F SPersico, NJani, J CPlasencia, WGreco, EPapaioannou, GWright, DNicolaides, K H2023-01-252023-01-252018-06-05http://hdl.handle.net/10668/12406To examine the effect of first-trimester screening for pre-eclampsia (PE) on the prediction of delivering a small-for-gestational-age (SGA) neonate and the effect of prophylactic use of aspirin on the prevention of SGA. The data for this study were derived from two multicenter studies. In SPREE, we investigated the performance of screening for PE by a combination of maternal characteristics and biomarkers at 11-13 weeks' gestation. In ASPRE, women with a singleton pregnancy identified by combined screening as being at high risk for preterm PE (> 1 in 100) participated in a trial of aspirin (150 mg/day from 11-14 until 36 weeks' gestation) compared to placebo. In this study, we used the data from the ASPRE trial to estimate the effect of aspirin on the incidence of SGA with birth weight  1 in 100) participated in a trial of aspirin (150 mg/day from 11-14 until 36 weeks' gestation) compared to placebo. In this study, we used the data from the ASPRE trial to estimate the effect of aspirin on the incidence of SGA with birth weight  1 in 100. In SPREE, screening for preterm PE by a combination of maternal factors, mean arterial pressure, uterine artery pulsatility index and serum placental growth factor identified a high-risk group that contained about 46% of SGA neonates First-trimester screening for PE by the combined test identifies a high proportion of cases of preterm SGA that can be prevented by the prophylactic use of aspirin. © 2018 Crown copyright. Ultrasound in Obstetrics & Gynecology © 2018 ISUOG.enASPRESPREEaspirinfetal growth restrictionfirst-trimester screeningpre-eclampsiasmall-for-gestational ageAdultAspirinBiomarkersFemaleFetal Growth RetardationGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgeMass ScreeningPlacenta Growth FactorPlatelet Aggregation InhibitorsPre-EclampsiaPredictive Value of TestsPregnancyPregnancy Trimester, FirstPregnancy-Associated Plasma Protein-APrenatal DiagnosisUterine Arteryresearch article29704277open access10.1002/uog.190771469-0705https://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.19077