Kretschmer, Alexandervan den Bergh, Roderick C NMartini, AlbertoMarra, GiancarloValerio, MassimoTsaur, IgorHeidegger, IsabelKasivisvanathan, VeeruKesch, ClaudiaPreisser, FelixFankhauser, Christian DZattoni, FabioCeci, FrancescoOlivier, JonathanChiu, PeterPuche-Sanz, IgnacioThibault, ConstanceGandaglia, GiorgioTilki, Derya2023-05-032023-05-032021-12-25Kretschmer A, van den Bergh RCN, Martini A, Marra G, Valerio M, Tsaur I, et al. Assessment of Health-Related Quality of Life in Patients with Advanced Prostate Cancer-Current State and Future Perspectives. Cancers (Basel). 2021 Dec 29;14(1):147.2072-6694http://hdl.handle.net/10668/20862With the therapeutic landscape of advanced prostate cancer rapidly evolving and oncological benefits being shown for a plethora of new agents and indications, health-related quality of life (HRQOL)-associated evidence is still subpar. In the current comprehensive review, we discuss the importance of HRQOL for patients with advanced PC (metastatic hormone-sensitive prostate cancer (mHSPC), metastatic castration-resistant prostate cancer (mCRPC) and non-metastatic castration-resistant prostate cancer (nmCRPC)), and present the most frequently used tools to evaluate HRQOL in recent randomized trials. Furthermore, we discuss the ease of use of these validated questionnaires for clinicians and try to focus on the suggested appropriate use in clinical practice, as well as potential strategies for improvement of HRQOL evaluation in these clinical scenarios of advanced prostate cancer.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/EQ-5DFACT-PQLQ-C30health-related quality of lifemetastaticprostate cancerHumansMaleProstatic Neoplasms, Castration-ResistantQuality of LifeSurveys and QuestionnairesPigmentation DisordersHormonesresearch article35008310open accessCalidad de vidaEncuestas y cuestionariosHormonasHumanosMasculinoNeoplasias de la próstata resistentes a la castraciónTrastornos de la pigmentación10.3390/cancers14010147PMC8749907https://www.mdpi.com/2072-6694/14/1/147/pdf?version=1640764805https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749907/pdf