Trubetskoy, VassilyPardiñas, Antonio FQi, TingPanagiotaropoulou, GeorgiaAwasthi, SwapnilBigdeli, Tim BBryois, JulienChen, Chia-YenDennison, Charlotte AHall, Lynsey SLam, MaxWatanabe, KyokoFrei, OleksandrGe, TianHarwood, Janet CKoopmans, FrankMagnusson, SigurdurRichards, Alexander LSidorenko, JuliaWu, YangZeng, JianGrove, JakobKim, MinsooLi, ZhiqiangVoloudakis, GeorgiosZhang, WenAdams, MarkAgartz, IngridAtkinson, Elizabeth GAgerbo, EsbenAl Eissa, MariamAlbus, MargotAlexander, MadelineAlizadeh, Behrooz ZAlptekin, KöksalAls, Thomas DAmin, FarooqArolt, VolkerArrojo, ManuelAthanasiu, LaviniaAzevedo, Maria HelenaBacanu, Silviu ABass, Nicholas JBegemann, MartinBelliveau, Richard ABene, JuditBenyamin, BebenBergen, Sarah EBlasi, GiuseppeBobes, JulioBonassi, StefanoBraun, AliceBressan, Rodrigo AffonsecaBromet, Evelyn JBruggeman, RichardBuckley, Peter FBuckner, Randy LBybjerg-Grauholm, JonasCahn, WiepkeCairns, Murray JCalkins, Monica ECarr, Vaughan JCastle, DavidCatts, Stanley VChambert, Kimberley DChan, Raymond C KChaumette, BorisCheng, WeiCheung, Eric F CChong, Siow AnnCohen, DavidConsoli, AngèleCordeiro, QuirinoCostas, JavierCurtis, CharlesDavidson, MichaelDavis, Kenneth Lde Haan, LieuweDegenhardt, FranziskaDeLisi, Lynn EDemontis, DitteDickerson, FaithDikeos, DimitrisDinan, TimothyDjurovic, SrdjanDuan, JubaoDucci, GiuseppeDudbridge, FrankEriksson, Johan GFañanás, LourdesFaraone, Stephen VFiorentino, AlessiaForstner, AndreasFrank, JosefFreimer, Nelson BFromer, MenachemFrustaci, AlessandraGadelha, AryGenovese, GiulioGershon, Elliot SGiannitelli, MariannaGiegling, InaGiusti-Rodríguez, PaolaGodard, StephanieGoldstein, Jacqueline IGonzález Peñas, JavierGonzález-Pinto, AnaGopal, SrihariGratten, JacobGreen, Michael FGreenwood, Tiffany AGuillin, OlivierGülöksüz, SinanGur, Raquel EGur, Ruben CGutiérrez, BlancaHahn, EricHakonarson, HakonHaroutunian, VahramHartmann, Annette MHarvey, CarolHayward, CarolineHenskens, Frans AHerms, StefanHoffmann, PerHowrigan, Daniel PIkeda, MasashiIyegbe, ConradJoa, IngeJulià, AntonioKähler, Anna KKam-Thong, TonyKamatani, YoichiroKarachanak-Yankova, SenaKebir, OussamaKeller, Matthew CKelly, Brian JKhrunin, AndreyKim, Sung-WanKlovins, JanisKondratiev, NikolayKonte, BettinaKraft, JuliaKubo, MichiakiKučinskas, VaidutisKučinskiene, Zita AusreleKusumawardhani, AgungKuzelova-Ptackova, HanaLandi, StefanoLazzeroni, Laura CLee, Phil HLegge, Sophie ELehrer, Douglas SLencer, RebeccaLerer, BernardLi, MiaoxinLieberman, JeffreyLight, Gregory ALimborska, SvetlanaLiu, Chih-MinLönnqvist, JoukoLoughland, Carmel MLubinski, JanLuykx, Jurjen JLynham, AmyMacek, MilanMackinnon, AndrewMagnusson, Patrik K EMaher, Brion SMaier, WolfgangMalaspina, DoloresMallet, JacquesMarder, Stephen RMarsal, SaraMartin, Alicia RMartorell, LourdesMattheisen, ManuelMcCarley, Robert WMcDonald, ColmMcGrath, John JMedeiros, HelenaMeier, SandraMelegh, BelaMelle, IngridMesholam-Gately, Raquelle IMetspalu, AndresMichie, Patricia TMilani, LiliMilanova, VihraMitjans, MarinaMolden, EspenMolina, EstherMolto, María DoloresMondelli, ValeriaMoreno, CarmenMorley, Christopher PMuntané, GerardMurphy, Kieran CMyin-Germeys, InezNenadić, IgorNestadt, GeraldNikitina-Zake, LieneNoto, CristianoNuechterlein, Keith HO'Brien, Niamh LouiseO'Neill, F AnthonyOh, Sang-YunOlincy, AnnOta, Vanessa KiyomiPantelis, ChristosPapadimitriou, George NParellada, MaraPaunio, TiinaPellegrino, RenataPeriyasamy, SathishPerkins, Diana OPfuhlmann, BrunoPietiläinen, OlliPimm, JonathanPorteous, DavidPowell, JohnQuattrone, DiegoQuested, DigbyRadant, Allen DRampino, AntonioRapaport, Mark HRautanen, AnnaReichenberg, AbrahamRoe, CherylRoffman, Joshua LRoth, JulianRothermundt, MatthiasRutten, Bart P FSaker-Delye, SafaaSalomaa, VeikkoSanjuan, JulioSantoro, Marcos LeiteSavitz, AdamSchall, UlrichScott, Rodney JSeidman, Larry JSharp, Sally IsabelShi, JianxinSiever, Larry JSigurdsson, EngilbertSim, KangSkarabis, NoraSlominsky, PetrSo, Hon-CheongSobell, Janet LSöderman, ErikStain, Helen JSteen, Nils EielSteixner-Kumar, Agnes AStögmann, ElisabethStone, William SStraub, Richard EStreit, FabianStrengman, EricStroup, T ScottSubramaniam, MythilySugar, Catherine ASuvisaari, JaanaSvrakic, Dragan MSwerdlow, Neal RSzatkiewicz, Jin PTa, Thi Minh TamTakahashi, AtsushiTerao, ChikashiThibaut, FlorenceToncheva, DragaTooney, Paul ATorretta, SilviaTosato, SarahTura, Gian BattistaTuretsky, Bruce IÜçok, AlpVaaler, Arnevan Amelsvoort, Theresevan Winkel, RuudVeijola, JuhaWaddington, JohnWalter, HenrikWaterreus, AnnaWebb, Bradley TWeiser, MarkWilliams, Nigel MWitt, Stephanie HWormley, Brandon KWu, Jing QinXu, ZhidaYolken, RobertZai, Clement CZhou, WeiZhu, FengZimprich, FritzAtbaşoğlu, Eşref CemAyub, MuhammadBenner, ChristianBertolino, AlessandroBlack, Donald WBray, Nicholas JBreen, GeromeBuccola, Nancy GByerley, William FChen, Wei JCloninger, C RobertCrespo-Facorro, BenedictoDonohoe, GaryFreedman, RobertGalletly, CherrieGandal, Michael JGennarelli, MassimoHougaard, David MHwu, Hai-GwoJablensky, Assen VMcCarroll, Steven AMoran, Jennifer LMors, OleMortensen, Preben BMüller-Myhsok, BertramNeil, Amanda LNordentoft, MeretePato, Michele TPetryshen, Tracey LPirinen, MattiPulver, Ann ESchulze, Thomas GSilverman, Jeremy MSmoller, Jordan WStahl, Eli ATsuang, Debby WVilella, ElisabetWang, Shi-HengXu, ShuhuaIndonesia Schizophrenia ConsortiumPsychENCODEPsychosis Endophenotypes International ConsortiumSynGO ConsortiumAdolfsson, RolfArango, CelsoBaune, Bernhard TBelangero, Sintia IoleBørglum, Anders DBraff, DavidBramon, ElviraBuxbaum, Joseph DCampion, DominiqueCervilla, Jorge ACichon, SvenCollier, David ACorvin, AidenCurtis, DavidForti, Marta DiDomenici, EnricoEhrenreich, HanneloreEscott-Price, ValentinaEsko, TõnuFanous, Ayman HGareeva, AnnaGawlik, MichaGejman, Pablo VGill, MichaelGlatt, Stephen JGolimbet, VeraHong, Kyung SueHultman, Christina MHyman, Steven EIwata, NakaoJönsson, Erik GKahn, René SKennedy, James LKhusnutdinova, ElzaKirov, GeorgeKnowles, James AKrebs, Marie-OdileLaurent-Levinson, ClaudineLee, JimmyLencz, ToddLevinson, Douglas FLi, Qingqin SLiu, JianjunMalhotra, Anil KMalhotra, DheerajMcIntosh, AndrewMcQuillin, AndrewMenezes, Paulo RMorgan, Vera AMorris, Derek WMowry, Bryan JMurray, Robin MNimgaonkar, VishwajitNöthen, Markus MOphoff, Roel APaciga, Sara APalotie, AarnoPato, Carlos NQin, ShengyingRietschel, MarcellaRiley, Brien PRivera, MargaritaRujescu, DanSaka, Meram CSanders, Alan RSchwab, Sibylle GSerretti, AlessandroSham, Pak CShi, YongyongSt Clair, DavidStefánsson, HreinnStefansson, KariTsuang, Ming Tvan Os, JimVawter, Marquis PWeinberger, Daniel RWerge, ThomasWildenauer, Dieter BYu, XinYue, WeihuaHolmans, Peter APocklington, Andrew JRoussos, PanosVassos, EvangelosVerhage, MatthijsVisscher, Peter MYang, JianPosthuma, DanielleAndreassen, Ole AKendler, Kenneth SOwen, Michael JWray, Naomi RDaly, Mark JHuang, HailiangNeale, Benjamin MSullivan, Patrick FRipke, StephanWalters, James T RO'Donovan, Michael CSchizophrenia Working Group of the Psychiatric Genomics Consortium2023-05-032023-05-032022-04-08http://hdl.handle.net/10668/19569Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.enAllelesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansPolymorphism, Single NucleotideSchizophreniaresearch article35396580open access10.1038/s41586-022-04434-51476-4687PMC9392466https://opinvisindi.is/bitstream/20.500.11815/4104/1/s41586_022_04434_5.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392466/pdf