Baena-Garcia, LauraAparicio, Virginia AMolina-Lopez, AnaAranda, PilarCamara-Roca, LauraOcon-Hernandez, Olga2023-05-032023-05-032022-06-16Baena-García L, Aparicio VA, Molina-López A, Aranda P, Cámara-Roca L, Ocón-Hernández O. Premenstrual and menstrual changes reported after COVID-19 vaccination: The EVA project. Womens Health (Lond). 2022 Jan-Dec;18:8http://hdl.handle.net/10668/20226Menstrual disorders were not reported as a possible secondary effect in any of the clinical trials for the SARS-CoV-2 vaccines. To describe the prevalence of perceived premenstrual and menstrual changes after COVID-19 vaccine administration. Cross-sectional study. A total of 14,153 women (mean age 31.5 ± 9.3 years old) who had received the full course of vaccination at least three months earlier were included in this cross-sectional study. Data including the type of vaccine administered, perceived changes in the amount and duration of menstrual bleeding, presence of clots, cycle length, and premenstrual symptoms were collected through a retrospective online survey from June to September 2021. Of the women who participated in this study, 3136 reported no menstrual changes and 11,017 (78% of the study sample) reported experiencing menstrual cycle changes after vaccination. In summary, women who reported menstrual changes after vaccination were older (overall p  Women vaccinated against COVID-19 usually perceive mild menstrual and premenstrual changes. Future studies are warranted to clarify the physiological mechanisms behind these widely reported changes.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/SARS-CoV-2fatigueimmunizationmenstrual bleedingmenstrual cyclepainAdultFemaleHumansYoung AdultCOVID-19COVID-19 VaccinesCross-Sectional StudiesMenstrual CycleMenstruationMenstruation DisturbancesPremenstrual SyndromeRetrospective StudiesSARS-CoV-2Vaccinationresearch article35833668open accessAdultoAdulto jovenCiclo menstrualEstudios retrospectivosEstudios transversalesFemeninoHumanosMenstruaciónSARS-CoV-2Síndrome premenstrualTrastornos de la menstruaciónVacunaciónVacunas contra la COVID-1910.1177/174550572211122371745-5065PMC9289916https://journals.sagepub.com/doi/pdf/10.1177/17455057221112237https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289916/pdf