Erton, Zeynep BelceSevim, Ecemde Jesús, Guilherme RamiresCervera, RicardJi, LanlanPengo, VittorioUgarte, AmaiaAndrade, DanieliAndreoli, LauraAtsumi, TatsuyaFortin, Paul RGerosa, MariaZuo, YuPetri, MichelleSciascia, SavinoTektonidou, Maria GAguirre-Zamorano, Maria AngelesBranch, D WareErkan, DorukAPS ACTION2023-05-032023-05-0320222053-8790http://hdl.handle.net/10668/20164To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry. We identified persistently aPL-positive patients recorded as 'pregnant' during prospective follow-up, and defined 'aPL-related outcome' as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment. Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss In our multicentre, international, aPL-positive cohort, of 55 first pregnancies observed prospectively, 15 (27%) were complicated by early pregnancy loss. Of the remaining 40 pregnancies, composite pregnancy morbidity was observed in 9 (23%) pregnancies.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/antibodies, anticardiolipinantibodies, antiphospholipidantiphospholipid syndromeAbortion, SpontaneousAntibodies, AntiphospholipidAntiphospholipid SyndromeFemaleFetal DeathHumansInfant, NewbornLupus Erythematosus, SystemicPlacentaPre-EclampsiaPregnancyPregnancy OutcomeProspective StudiesRegistriesresearch article35701043open access10.1136/lupus-2021-000633PMC9198709https://lupus.bmj.com/content/lupusscimed/9/1/e000633.full.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198709/pdf