Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study.

Castro-Barquero, SaraTresserra-Rimbau, AnnaVitelli-Storelli, FacundoDomenech, MonicaSalas-Salvado, JordiMartin-Sanchez, VicenteRubin-Garcia, MariaBuil-Cosiales, PilarCorella, DoloresFito, MontserratRomaguera, DoraVioque, JesusAlonso-Gomez, Angel MaríaWärnberg, JuliaMartinez, Jose AlfredoSerra-Majem, LuisTinahones, Francisco JoseLapetra, JosePinto, XavierTur, Josep AntonioGarcia-Rios, AntonioGarcia-Molina, LauraDelgado-Rodriguez, MiguelMatia-Martin, PilarDaimiel, LidiaVidal, JosepVazquez, ClotildeCofan, MontserratRomanos-Nanclares, AndreaBecerra-Tomas, NereaBarragan, RocioCastañer, OlgaKonieczna, JadwigaGonzalez-Palacios, SandraSorto-Sanchez, CarolinaPerez-Lopez, JessicaZulet, María AngelesBautista-Castaño, InmaculadaCasas, RosaGomez-Perez, Ana MariaSantos-Lozano, Jose ManuelRodriguez-Sanchez, Maria AngelesJulibert, AliciaMartin-Calvo, NereaHernandez-Alonso, PabloSorli, Jose VSanllorente, AlbertGalmes-Panades, Aina MariaCases-Perez, EugenioGoicolea-Güemez, LeireRuiz-Canela, MiguelBabio, NancyHernaez, AlvaroLamuela-Raventos, Rosa MariaEstruch, Ramon2023-02-082023-02-082020-02-29Castro-Barquero S, Tresserra-Rimbau A, Vitelli-Storelli F, Doménech M, Salas-Salvadó J, Martín-Sánchez V, et al. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study. Nutrients. 2020 Mar 4;12(3):689.http://hdl.handle.net/10668/15210Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HDL-cholesterolMediterranean dietglignansmetabolic syndromepolyphenolsstilbenesAgedBiomarkersBody Mass IndexCholesterol, HDLCross-Sectional StudiesDiet, MediterraneanDietary SupplementsFemaleHumansMaleMetabolic SyndromeMiddle AgedPatient Outcome AssessmentPolyphenolsPublic Health SurveillanceDietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study.research article32143308open accessAncianoBiomarcadoresDieta MediterráneaEstudios transversalesEvaluación del resultado de la atención al pacienteFemeninoHDL-ColesterolHumanosMasculinoPersona de mediana edadPolifenolesSuplementos dietéticosSíndrome metabólicoVigilancia en salud públicaÍndice de Masa Corporal10.3390/nu120306892072-6643PMC7146338https://www.mdpi.com/2072-6643/12/3/689/pdf?version=1583319042https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146338/pdf