Blánquez-Martínez, DavidDíaz-Villamarín, XandoAntúnez-Rodríguez, AlbaPozo-Agundo, AnaMuñoz-Ávila, José IgnacioMartínez-González, Luis JavierDávila-Fajardo, Cristina Lucía2022-09-062022-09-062021-11-20Blánquez-Martínez D, Díaz-Villamarín X, Antúnez-Rodríguez A, Pozo-Agundo A, Muñoz-Ávila JI, Martínez-González LJ, et al. Genetic Polymorphisms Affecting Ranibizumab Response in High Myopia Patients. Pharmaceutics. 2021 Nov 20;13(11):1973http://hdl.handle.net/10668/4001High myopia is an ophthalmic pathology that affects half of the young adults in the United States and Europe and it is predicted that a third of the world's population could be nearsighted at the end of this decade. It is characterized by at least 6 diopters or axial length > 26 mm and, choroidal neovascularization (CNV) in 5 to 11% of cases. Ranibizumab is a recombinant humanized monoclonal antibody fragment. It is an anti-vascular endothelial growth factor (anti-VEGF) drug used in the treatment of CNV. Many genetic polymorphisms have been associated with interindividual differences in the response to ranibizumab, but these associations were not yet assessed among patients with high myopia and CNV. We performed a retrospective study assessing the association of genetic polymorphisms with response to ranibizumab in patients with CNV secondary to high myopia (mCNV). We included genetic polymorphisms previously associated with the response to drugs used in CNV patients (bevacizumab, ranibizumab, aflibercept, and photodynamic therapy (PDT)). We also included genetic variants in the VEGFA gene. Based on our results, ARMS2 (rs10490924) and CFH (rs1061170) are associated with response to ranibizumab in high myopia patients; and, included VEGFA genetic polymorphisms are not associated with ranibizumab response in our population but might be related to a higher risk of CNV.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/MyopiaPharmacogeneticGenetic polymorphismPersonalized medicineRanibizumabAnti-VEGFVEGFACFHARMS2MiopíaPruebas de farmacogenómicaPolimorfismo genéticoMedicina de precisiónFactores de crecimiento endotelialFactor A de crecimiento endotelial vascularMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Persons::Persons::Age Groups::Adult::Young AdultMedical Subject Headings::Geographical Locations::Geographic Locations::Americas::North America::United StatesMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Metaplasia::Neovascularization, Pathologic::Choroidal NeovascularizationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective StudiesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::PhototherapyMedical Subject Headings::Diseases::Eye Diseases::Refractive Errors::MyopiaMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, GeneticMedical Subject Headings::Geographical Locations::Geographic Locations::Europeresearch article34834388open access10.3390/pharmaceutics131119731999-4923PMC8620862