Vázquez-Marrufo, ManuelGonzález-Rosa, Javier JGalvao-Carmona, AlejandroHidalgo-Muñoz, AntonioBorges, MónicaRuiz Peña, Juan LuisIzquierdo, Guillermo2015-11-232015-11-232013-05-01Vázquez-Marrufo M, González-Rosa JJ, Galvao-Carmona A, Hidalgo-Muñoz A, Borges M, Peña JL, et al. Retest reliability of individual p3 topography assessed by high density electroencephalography. PLoS ONE. 2013; 8(5):e62523http://hdl.handle.net/10668/2071Journal Article; Research Support, Non-U.S. Gov't;BACKGROUND Some controversy remains about the potential applicability of cognitive potentials for evaluating the cerebral activity associated with cognitive capacity. A fundamental requirement is that these neurophysiological parameters show a high level of stability over time. Previous studies have shown that the reliability of diverse parameters of the P3 component (latency and amplitude) ranges between moderate and high. However, few studies have paid attention to the retest reliability of the P3 topography in groups or individuals. Considering that changes in P3 topography have been related to different pathologies and healthy aging, the main objective of this article was to evaluate in a longitudinal study (two sessions) the reliability of P3 topography in a group and at the individual level. RESULTS The correlation between sessions for P3 topography in the grand average of groups was high (r = 0.977, p<0.001). The within-subject correlation values ranged from 0.626 to 0.981 (mean: 0.888). In the between-subjects topography comparisons, the correlation was always lower for comparisons between different subjects than for within-subjects correlations in the first session but not in the second session. CONCLUSIONS The present study shows that P3 topography is highly reliable for group analysis (comprising the same subjects) in different sessions. The results also confirmed that retest reliability for individual P3 maps is suitable for follow-up studies for a particular subject. Moreover, P3 topography appears to be a specific marker considering that the between-subjects correlations were lower than the within-subject correlations. However, P3 topography appears more similar between subjects in the second session, demonstrating that is modulated by experience. Possible clinical applications of all these results are discussed.enElectroencefalografíaPotenciales relacionados con Evento P300Estimulación luminosaReproducibilidad de resultadosMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::BrainMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::CognitionMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Neurological::ElectroencephalographyMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Electrophysiological Phenomena::Evoked Potentials::Event-Related Potentials, P300Medical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Physical Stimulation::Photic StimulationMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Reaction TimeMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of ResultsMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young AdultMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article23658739open access10.1371/journal.pone.00625231932-6203PMC3641033