Reyes-Ferrada, WaleskaSolis-Urra, PatricioPlaza-Díaz, JulioSadarangani, Kabir Pde Moraes Ferrari, Gerson LuisRodríguez-Rodríguez, FernandoCristi-Montero, Carlos2023-02-082023-02-082020-04-28Reyes-Ferrada W, Solis-Urra P, Plaza-Díaz J, Sadarangani KP, de Moraes Ferrari GL, Rodríguez-Rodríguez F, et al. Cardiorespiratory Fitness, Physical Activity, Sedentary Time and Its Association with the Atherogenic Index of Plasma in Chilean Adults: Influence of the Waist Circumference to Height Ratio. Nutrients. 2020 Apr 28;12(5):1250.http://hdl.handle.net/10668/15472Atherogenic index of plasma (AIP) is a novel biomarker related to cardiovascular disease (CVD). Cardiorespiratory fitness (CRF) and physical activity (PA) have an inverse relationship with the AIP, while sedentary time (ST) and fatness present a positive association . This study aimed to determine the combined and independent association of CRF, PA, and ST with the AIP, and additionally to establish the waist-to-height ratio (WHtR) mediation role . Data from the Chilean national health survey were used (4671 adults ). A PACS ( Physical Activity Cardiorespiratory Sedentary) score was created ranging from 0 to 3, indicating the number of positive recommendations met (PA, ST, and CRF). AIP was calculated (Log10 triglycerides / high-density lipoprotein - cholesterol ). The combined analysis showed that compared to those with a PACS score of 0, those with a score of 1 or 2 did not present significantly reduced AIP values (adjusted by the WHtR); however, those with a score of 3 did (OR (odds ratio) = 0.50; 95% CI, 0.32 to 0.77; p < 0.001). Independent analysis showed that CRF seems to be the only variable that supports the combined result (β = −0.212; p < 0.001). Finally, the mediation analysis indicated that the WHtR mediated the association between CRF and the AIP in 34.2% of cases. Overall, only CRF had a significant and inverse association with the AIP. Nonetheless, around one-third of this beneficial relationship is affected by an elevated WHtR.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/adipositycardiovascular riskepidemiologyhealthy lifestyleslipid profileAdultAtherosclerosisBiomarkersBody HeightCardiorespiratory FitnessCardiovascular DiseasesChileCross-Sectional StudiesData AnalysisDatabases, FactualExerciseFemaleGovernment AgenciesHealth SurveysHumansLipoproteins, HDLMaleSedentary BehaviorTime FactorsTriglyceridesWaist Circumferenceresearch article32354005open accessAsociaciónEjercicio físicoAnálisis de mediaciónEncuestas epidemiológicasConducta sedentariaEnfermedades cardiovascularesBiomarcadoresLipoproteínas HDLTriglicéridosColesterol10.3390/nu120512502072-6643PMC7281995https://www.mdpi.com/2072-6643/12/5/1250/pdf?version=1588070091https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281995/pdf