Bellver, JoséBosch, ErnestoEspinós, Juan JoséFabregues, FranciscoFontes, JuanGarcía-Velasco, JuanLlácer, JoaquínRequena, AntonioCheca, Miguel AngelSpanish Infertility SWOT Group (SISG)2023-02-082023-02-082019-08-13http://hdl.handle.net/10668/15433Second-generation preimplantation genetic testing for aneuploidy (PGT-A 2.0) in patients with an unfavourable reproductive and IVF prognosis is becoming common practice, with the aim of improving reproductive outcomes. However, there is still no clear evidence on the possible advantages and drawbacks with regard to this procedure. In this discussion paper, based on a SWOT (strengths, weaknesses, opportunities, threats) analysis, the different aspects of this strategy are evaluated. Current evidence suggests that PGT-A 2.0 should not at present have an indiscriminate application, but it might be indicated in cases in which the risk of aneuploidy is increased.enAssisted reproductionBlastocyst biopsyImplantationInfertilityLive birthPreimplantation genetic testingAbortion, SpontaneousAneuploidyFemaleGenetic TestingHumansPregnancyPregnancy RatePreimplantation Diagnosisresearch article31653432open access10.1016/j.rbmo.2019.07.0371472-6491http://www.rbmojournal.com/article/S1472648319306959/pdf