Toapanta Gaibor, Néstor GabrielNava Pérez, Nathasha CarolinaMartínez Echevers, YeleineMontes Delgado, RafaelGuerrero Riscos, María Ángeles2023-01-252023-01-252016-11-05http://hdl.handle.net/10668/10592At present, there is a high incidence of elderly patients with advanced chronic kidney disease (CKD) and it is important to know the long term progression and the factors that influence it. To analyse the progression of advanced CKD in elderly patients and the influence of bone-mineral metabolism. Retrospective study of 125 patients ≥70years of age with CKD stages 4-5 who started follow-up from January 1, 2007 to December 31, 2008, showing the progression of CKD (measured by the slope of the regression line of the estimated glomerular filtration rate [eGFR] by MDRD-4) over 5years. Progression in the entire group (median and 25th and 75th percentiles): -1.15 (-2.8/0.17) ml/min/1.73m2/year, CKD-4: -1.3 (-2.8/0.03) ml/min/1.73m2/year, CKD-5: -1.03 (-3.0/0.8) ml/min/1.73m2/year; the slope of the regression line was positive in 35 patients (28%: CKD does not progress) and negative in 90 patients (72%: CKD progresses). Negative correlation (Spearman) (slower progression): PTH, albumin/Cr ratio and daily Na excretion (all baseline measurements). No correlation with eGFR, serum P, urinary P excretion, protein intake and intake of P (all baseline measurements). In the linear regression analysis (dependent variable: slope of progression): albuminuria and PTH (both at baseline measurements) influenced this variable independently. Logistic regression (progresses vs. does not progress): PTH, albuminuria and eGFR (all at baseline measurements) influenced significantly. In our group of elderly patients, impairment of renal function is slow, particularly in CKD-5 patients. Albuminuria and PTH at baseline levels are prognostic factors in the evolution of renal function.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Advanced chronic kidney diseaseAncianosBone mineral metabolismChronic kidney diseaseElderly patients.Enfermedad renal crónicaEnfermedad renal crónica avanzadaFósforo séricoMetabolismo óseo mineralPredialysisPrediálisisProgresión de enfermedad renalProgression of kidney diseaseSerum phosphorusAgedDisease ProgressionFemaleHumansKidney Failure, ChronicLongitudinal StudiesMaleParathyroid HormonePhosphorusPrognosisRetrospective Studiesresearch article27823902open access10.1016/j.nefro.2016.08.0041989-2284https://doi.org/10.1016/j.nefro.2016.08.004