de Miguel-Yanes, Jose M.Lopez-de-Andres, AnaJiménez-Garcia, RodrigoHernandez-Barrera, Valentinde Miguel-Diez, JavierCarabantes-Alarcon, DavidPerez-Farinos, NapoleonWärnberg, Julia2022-08-092022-08-092021-09-23de Miguel-Yanes JM, Lopez-de-Andres A, Jiménez-Garcia R, Hernandez-Barrera V, de Miguel-Diez J, Carabantes-Alarcon D, et al. Incidence, Outcomes and Sex-Related Disparities in Pneumonia: A Matched-Pair Analysis with Data from Spanish Hospitals (2016-2019). J Clin Med. 2021 Sep 23;10(19):4339http://hdl.handle.net/10668/3902Background: the purpose of this study is to analyze the incidence and in-hospital mortality (IHM) of community-acquired pneumonia (CAP) needing hospital admission and hospital-acquired pneumonia (HAP) in Spain (2016-2019). Methods: using the Spanish Register of Specialized Care-Basic Minimum Database, we estimated the incidence of CAP and HAP. We matched each woman with a man with an identical age, according to comorbidities. Results: we analyzed 518,838 cases of CAP and 38,705 cases of HAP, and 5192 ventilator-associated HAPs (13.4%). The incidence of CAP increased over time in both men (from 384.5 to 449.8 cases/105 population) and women (from 244.9 to 301.2 cases/105 population). Men showed a 47% higher adjusted incidence of CAP than women. The incidence of HAP increased over time in both men (from 302.3 to 342.2 cases/105 population) and women (from 139.2 to 167.6 cases/105 population). Men showed a 98% higher adjusted incidence of HAP than women. IHM was higher in men admitted for CAP than in women (12.9% vs. 12.2%; p < 0.001), but not in men who developed HAP (28.9% vs. 28.0%; p = 0.107). Men admitted for CAP (OR: 1.13; 95% CI: 1.10-1.15) and men who developed HAP (OR: 1.05; 95% CI: 1.01-1.10) had higher IHM than women. Conclusions: men had higher incidence rates of CAP and HAP than women. Men admitted for CAP and men who developed HAP had higher IHM than women.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Community-acquired pneumoniaHospital-acquired pneumoniaVentilator-associated pneumoniaGenderSex differencesIn-hospital mortalityNeumonía asociada al cuidado de la saludNeumonía asociada al ventiladorGénero y saludCaracterísticas sexualesMortalidad hospitalariaMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::IncidenceMedical Subject Headings::Health Care::Population Characteristics::Demography::Vital Statistics::Mortality::Hospital MortalityMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::SpainMedical Subject Headings::Diseases::Respiratory Tract Diseases::Respiratory Tract Infections::PneumoniaMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Ventilators, MechanicalMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::HospitalsMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-AssociatedMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sex Characteristicsresearch article34640357Acceso abierto10.3390/jcm101943392077-0383PMC8509552