Santos Garcia, D.De Deus Fonticoba, T.Paz Gonzalez, J. M.Cores Bartolome, C.Valdes Aymerich, L.Munoz Enriquez, J. G.Suarez, E.Jesus, S.Aguilar, M.Pastor, P.Planellas, L. L.Cosgaya, M.Garcia Caldentey, J.Caballol, N.Legarda, I.Hernandez Vara, J.Cabo, I.Lopez Manzanares, L.Gonzalez Aramburu, I.Avila Rivera, M. A.Catalan, M. J.Nogueira, V.Puente, V.Garcia Moreno, J. M.Borrue, C.Solano Vila, B.Alvarez Sauco, M.Vela, L.Escalante, S.Cubo, E.Carrillo Padilla, F.Martinez Castrillo, J. C.Sanchez Alonso, P.Alonso Losada, M. G.Lopez Ariztegui, N.Gaston, I.Kulisevsky, J.Blazquez Estrada, M.Seijo, M.Ruiz Martinez, J.Valero, C.Kurtis, M.de Fabregues, O.Gonzalez Ardura, J.Ordas, C.Lopez Diaz, L.Mir, P.Martinez-Martin, P.COPPADIS Study Grp2023-02-122023-02-122021-05-152090-8083http://hdl.handle.net/10668/19080Introduction. In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS=0-20; B: NMSS=21-40; C: NMSS=41-70; D: NMSS >= 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p= 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ScaleQuestionnaireSubtypesImpactresearch articleopen access10.1155/2021/88715492042-0080https://downloads.hindawi.com/journals/pd/2021/8871549.pdf761375100001