Afram, GabrielSimón, Jose Antonio PérezRemberger, MatsCaballero-Velázquez, TeresaMartino, RodrigoPiñana, Jose LuisRingden, OlleEsquirol, AlbertLopez-Corral, LuciaGarcia, IreneLópez-Godino, OrianaSierra, JordiCaballero, DoloresLjungman, PerVazquez, LourdesHägglund, Hans2023-01-252023-01-252018-04-25http://hdl.handle.net/10668/12395Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ATGGraft-versus-host disease (GVHD)Risk factorAdolescentAdultAgedChildChild, PreschoolChronic DiseaseFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansInfantMaleMiddle AgedRetrospective StudiesRisk FactorsTransplantation ConditioningTransplantation, HomologousYoung Adultresearch article29696461open access10.1007/s12032-018-1127-21559-131XPMC5918523https://link.springer.com/content/pdf/10.1007/s12032-018-1127-2.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918523/pdf