Cavagna, LorenzoTrallero-Araguás, ErnestoMeloni, FedericaCavazzana, IlariaRojas-Serrano, JorgeFeist, EugenZanframundo, GiovanniMorandi, ValentinaMeyer, AlainPereira da Silva, Jose AntonioMatos Costa, Carlo JorgeMolberg, OyvindAndersson, HelenaCodullo, VeronicaMosca, MartaBarsotti, SimoneNeri, RossellaScirè, CarloGovoni, MarcelloFurini, FedericaLopez-Longo, Francisco JavierMartinez-Barrio, JuliaSchneider, UdoLorenz, Hanns-MartinDoria, AndreaGhirardello, AnnaOrtego-Centeno, NorbertoConfalonieri, MarcoTomietto, PaolaPipitone, NicolòRodriguez Cambron, Ana BelenBlázquez Cañamero, María ÁngelesVoll, Reinhard EdmundWendel, SarahScarpato, SalvatoreMaurier, FrancoisLimonta, MassimilianoColombelli, PaoloGiannini, MargheritaGeny, BernardArrigoni, EugenioBravi, ElenaMigliorini, PaolaMathieu, AlessandroPiga, MatteoDrott, UlrichDelbrueck, ChristianeBauhammer, JuttaCagnotto, GiovanniVancheri, CarloSambataro, GianlucaDe Langhe, EllenSainaghi, Pier PaoloMonti, CristinaGigli Berzolari, FrancescaRomano, MariaevaBonella, FrancescoSpecker, ChristofSchwarting, AndreasVilla Blanco, IgnacioSelmi, CarloCeribelli, AngelaNuno, LauraMera-Varela, AntonioPerez Gomez, NairFusaro, EnricoParisi, SimoneSinigaglia, LuigiDel Papa, NicolettaBenucci, MaurizioCimmino, Marco AmedeoRiccieri, ValeriaConti, FabrizioSebastiani, Gian DomenicoIuliano, AnnamariaEmmi, GiacomoCammelli, DanieleSebastiani, MarcoManfredi, AndreinaBachiller-Corral, JavierSifuentes Giraldo, Walter AlbertoPaolazzi, GiuseppeSaketkoo, Lesley AnnGiorgi, RobertoSalaffi, FaustoCifrian, JoseCaporali, RobertoLocatelli, FrancescoMarchioni, EnricoPesci, AlbertoDei, GiuliaPozzi, Maria RosaClaudia, LomaterDistler, JorgKnitza, JohannesSchett, GeorgeIannone, FlorenzoFornaro, MarcoFranceschini, FrancoQuartuccio, LucaGerli, RobertoBartoloni, ElenaBellando Randone, SilviaZampogna, GiuseppeGonzalez Perez, Montserrat IMejia, MayraVicente, EstherTriantafyllias, KonstantinosLopez-Mejias, RaquelMatucci-Cerinic, MarcoSelva-O'Callaghan, AlbertCastañeda, SantosMontecucco, CarlomaurizioGonzalez-Gay, Miguel Angel2023-02-082023-02-082019-11-182077-0383http://hdl.handle.net/10668/14721Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/antisynthetase antibodiesantisynthetase syndromearthritisinterstitial lung diseasemyositisresearch article31752231open access10.3390/jcm8112013PMC6912490https://www.mdpi.com/2077-0383/8/11/2013/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912490/pdf