Márquez-Coello, MercedesArizcorreta, AnaRodríguez-Pardo, MaríaIllanes-Álvarez, FranciscoMárquez, DenisseCuesta-Sancho, SaraGirón-González, José-Antonio2023-02-092023-02-092021-05-10http://hdl.handle.net/10668/17777The objective of this work was to identify predictive factors of fibrosis regression after direct antiviral agents (DAAs) in HCV-monoinfected and HIV/HCV-coinfected patients. This was a prospective study of HCV-monoinfected (n = 20), HIV/HCV-co-infected (n = 66) patients and healthy controls (n = 15). Patients had started DAAs and achieved sustained virological response. Liver stiffness (LS) and serum concentrations of profibrotic transforming growth factor (TGF)-β1 and CXC chemokine ligand 4 (CXCL4) and antifibrotic HGF hepatocyte growth factor (HGF) were analyzed at baseline (M0) and 12 months after starting DAAs (M12). A M12 LS achievement of ≤ 9.5 kPa was considered the cutoff point to discharge from a liver clinic. The LS decrease from M0 to M12 was 34%. No significant differences were observed in LS decline between HCV- and HIV/HCV-infected individuals. Changes of serum CXCL4, TGF-β1 and HGF levels did not correlate with LS improvement. 16 out from 56 patients (28%) with a baseline LS > 9.5 achieved a M12 LS ≤ 9.5. HCV-monoinfected and HIV/HCV coinfected patients experienced a significant reduction of LS after sustained virological response. This improvement did not correlate with changes in serum profibrotic or antifibrotic markers. A 29% of those with a baseline LS > 9.5 achieved a LS under this cutoff point.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AgedAntiviral AgentsBiomarkersCase-Control StudiesCoinfectionElasticity Imaging TechniquesFemaleFollow-Up StudiesHIV InfectionsHealthy VolunteersHepatitis C, ChronicHepatocyte Growth FactorHumansLiverLiver CirrhosisMaleMiddle AgedPlatelet Factor 4Prospective StudiesReference ValuesSustained Virologic ResponseTransforming Growth Factor beta1research article33972651open access10.1038/s41598-021-89370-62045-2322PMC8110591https://www.nature.com/articles/s41598-021-89370-6.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110591/pdf