Porras Segovia, AlejandroGuerrero-Jiménez, MargaritaCarrillo de Albornoz Calahorro, Carmen MauraGutierrez-Rojas, Luis2023-02-092023-02-092021-04-142517-729Xhttp://hdl.handle.net/10668/17736Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/cerebellar vermiscerebral ventriclespsychotic disordersschizophreniaschizophrenia spectrum and other psychotic disordersresearch article33937630open access10.1136/gpsych-2020-100254PMC8054076https://gpsych.bmj.com/content/gpsych/34/2/e100254.full.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054076/pdf