Marques, JoanaValle-Delgado, Juan JoséUrbán, PatriciaBaró, ElisabetProhens, RafelMayor, AlfredoCisteró, PauDelves, MichaelSinden, Robert EGrandfils, Christiande Paz, José LGarcía-Salcedo, José AFernàndez-Busquets, Xavier2017-04-182017-04-182017-02Marques J, Valle-Delgado JJ, Urbán P, Baró E, Prohens R, Mayor A et al.Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery. Nanomedicine. 2017 Feb;13(2):515-5251549-9634http://hdl.handle.net/10668/2612Patent application: Heparin-lipidic nanoparticle conjugates. Inventors: Fernàndez-Busquets, X., Marques, J., Moles, E. Institutions: IBEC, ISGlobal. Application number: EP13152187.4; priority country: Europe; priority date: January 22, 2013.The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.enGlycosaminoglycansMalariaNanomedicinePlasmodiumTargeted drug deliveryQuitosanoRecuento de eritrocitosAntimaláricosInsectos vectoresHeparinaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiparasitic Agents::Antiprotozoal Agents::AntimalarialsMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Chitin::ChitosanMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glycosaminoglycans::Chondroitin::Chondroitin SulfatesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Erythrocyte CountMedical Subject Headings::Anatomy::Hemic and Immune Systems::Blood::Blood Cells::ErythrocytesMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glycosaminoglycans::HeparinMedical Subject Headings::Chemicals and Drugs::LipidsMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Drug Carriers::LiposomesMedical Subject Headings::Diseases::Parasitic Diseases::Protozoan Infections::MalariaMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Transmission, Infectious::Disease Vectors::Arthropod Vectors::Insect Vectors::Mosquito VectorsMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::NanoparticlesMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::NanotechnologyMedical Subject Headings::Organisms::Eukaryota::Alveolata::Apicomplexa::Haemosporida::PlasmodiumMedical Subject Headings::Organisms::Eukaryota::Animalsresearch article27720930open access10.1016/j.nano.2016.09.0101549-9642PMC5332526