Medrano, Luz MGutierrez-Rivas, MonicaBlanco, JuliaGarcia, MarcialJimenez-Sousa, Maria APacheco, Yolanda MMontero, MartaIribarren, Jose AntonioBernal, EnriqueMartinez, Onofre JuanBenito, Jose MRallon, NormaResino, Salvador2023-01-252023-01-252018-12-06Medrano LM, Gutiérrez-Rivas M, Blanco J, García M, Jiménez-Sousa MA, Pacheco YM, et al. Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy. J Transl Med. 2018 Dec 6;16(1):343.http://hdl.handle.net/10668/13287The mitochondrial DNA ( mtDNA ) seems to influence in a large number of diseases , including HIV infection . Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV -infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV -infected patients on cART. Methods : This is a retrospective study of 324 naïve cART patients with CD4+ < 200 cells /mm3, who were followed-up during 24 months after initiating cART. All patients had undetectable HIV viral load during the follow-up. Besides, we included 141 healthy controls. MtDNA genotyping was performed by using Sequenom's MassARRAY platform. The primary outcome variable was the slope of CD4+ recovery. Patients were stratified into two groups by the median slope value of CD4+ (9.65 CD4+ cells /mm3/month). Logistic regression analyses were performed to calculate the odds of CD4+ recovery according to mtDNA haplogroups. Results: Our study included European HIV -infected patients within the N macro-cluster. The baseline values of CD4+ T-cells were similar between groups of patients stratified by the P50th of the slope of CD4+ T-cells recovery. Patients in the low CD4+ T-cells recovery group were older (p = 0.001), but this variable was included in the multivariate models. When we analyzed the frequencies of mtDNA haplogroups, no significant differences between HIV -infected individuals and healthy controls were found. We did not find any significant association between mtDNA haplogroups and the slope of CD4+ T-cells recovery by linear regression analysis. However, Patients carrying haplogroup H had a higher odds of having a better CD4+ recovery (> 9.65 CD4+ cells /mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells /mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035]. Conclusions: European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV -infected patients starting cART with CD4+ < 200 cells /mm3.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HIVHaplogroupsImmune reconstitutionMitochondriacARTmtDNAAdultAntiretroviral Therapy, Highly ActiveCD4-Positive T-LymphocytesCase-Control StudiesDNA, MitochondrialFemaleHIV InfectionsHaplotypesHumansMaleMitochondriaresearch article30522500open accessPacientesADN mitocondrialLinfocitos TCarga viralInfecciones por VIHTerapia antirretroviral altamente activa10.1186/s12967-018-1717-y1479-5876PMC6282399https://doi.org/10.1186/s12967-018-1717-yhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282399/pdf