Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study).

García de Guadiana-Romualdo, LuisMorell-García, DanielMorales-Indiano, CristianBauça, Josep MiquelAlcaide Martín, María JoséEsparza Del Valle, ClaraGutiérrez Revilla, Jose IUrrechaga, EloisaÁlamo, José MHernando Holgado, Ana MLorenzo-Lozano, María-CarmenSánchez Fdez-Pacheco, Silviade la Hera Cagigal, PatriciaJuncos Tobarra, María AVílchez, Juan AVírseda Chamorro, IsabelGutiérrez Garcia, IrenePastor Murcia, YolandaSahuquillo Frías, LauraAltimira Queral, LauraNuez-Zaragoza, ElisaAdell Ruiz de León, JuanRuiz Ripa, AliciaSalas Gómez-Pablos, PalomaCebreiros López, IriaFernández Uriarte, AmaiaLarruzea, ÁlexLópez Yepes, María LEsteban Torrella, PatriciaZamorano Andrés, María CPedregosa Díaz, JoseAcevedo Alcaraz, CristinaBlazquez-Manzanera, Alfonso-LPadilla Jiménez, Ana M LBaamonde Calzada, María CVera, MarinaCháfer Rudilla, MatildeCanalda Campás, MagdalenaGarcía Muñoz, SaraVicente Gutiérrez, LuisJiménez Añón, LauraPérez Martínez, AlfonsoPons Castillo, AurelioGonzález Tamayo, RuthFérriz Vivancos, JorgeRodríguez-Fraga, OlaiaFerrer Díaz de Brito Fernández, VicenteAguadero, VicenteGarcía Arévalo, María GArnaldos Carrillo, MaríaGonzález Morales, MercedesNúñez Gárate, MaríaRuiz Iruela, CristinaSancho-Rodríguez, NataliaVila Pérez, MartiEgea-Caparrós, José MSáenz, LuisBlasco Barbero, ÁlvaroGalán Ortega, Amparo2023-02-092023-02-092021-02-16http://hdl.handle.net/10668/17188Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.enCOVID-19adjustmentlaboratory testsmulticenter studyprognosisAdolescentAdultAgedAged, 80 and overCOVID-19Emergency Service, HospitalFemaleHospital MortalityHospitalizationHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2SpainYoung AdultCharacteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study).research article33591234open access10.1080/00365513.2021.18819971502-7686PMC7898295https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898295https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898295/pdf