Rosety-Rodriguez, MOrdonez, F JRosety, IFrias, LRosety, M ARosety, J MRosety, M2012-11-092012-11-092006-11Rosety-Rodriguez M, Ordonez FJ, Rosety I, Frias L, Rosety MA, Rosety JM, et al. 8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats. Histol. Histopathol.. 2006 Nov; 21(11):1167-700213-3911http://hdl.handle.net/10668/613Journal Article;In recent years it has been shown that emotional stress induced by immobilization may change the balance between pro-oxidant and antioxidant factors inducing oxidative damage. On the other hand, contradictory views exist concerning the role of physical activity on redox metabolism. Consequently, the present work was designed to assess the influence of an 8-week moderate swimming training program in emotionally stressed rats. Sixty 1-month-old male albino Wistar rats weighing 125-135 g were used in this experimental study. They were divided into three groups, as Control (lot A; n=20), Stressed (lot B; n=20) and Stressed & Exercised (lot C; n=20). Rats were stressed by placing the animals in a 25 x 7 cm plastic bottle 1 h/day, 5 days a week for 8 weeks. Protein carbonyl content values in liver homogenates were significantly increased in stressed animals (0.58+/-0.02 vs 0.86+/-0.03; p=0.018) which clearly indicated that emotional stress was associated with oxidative stress. Ultrastructural alterations, predominantly mitochondrial swelling and the decrease of cristae number observed by electron microscopy represented direct evidence of membrane injury. The most striking feature of our study was that we also found differences between stressed rats and stressed rats that performed our 8 week training program. Consequently our results highlight the potential benefit of a moderate training program to reduce oxidative damage induced by emotional stress since it attenuated protein oxidation and mitochondrial alterations.enExerciseMitochondriaOxidative StressEmotional stressEjercicioMitocondriasEstrés oxidativoEstrés emocionalConducta animalHígadoCondicionamiento físico animalRatasRatas WistarOxigenoMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavior, AnimalMedical Subject Headings::Anatomy::Digestive System::LiverMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::MitochondriaMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism::Oxidation-ReductionMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative StressMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Gases::OxygenMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Physical Conditioning, AnimalMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::RatsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, WistarMedical Subject Headings::Disciplines and Occupations::Human Activities::Leisure Activities::Recreation::Sports::RunningMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress, PsychologicalMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time FactorsMedical Subject Headings::Organisms::Eukaryota::Animalsresearch article16874659open access1699-5848