Vilar-Gomez, EduardoYasells-Garcia, AliMartinez-Perez, YadinaCalzadilla-Bertot, LuisTorres-Gonzalez, AnaGra-Oramas, BienvenidoGonzalez-Fabian, LicetVilla-Jimenez, OscarFriedman, Scott LDiago, MoisesRomero-Gomez, Manuel2023-01-252023-01-252016-03-10http://hdl.handle.net/10668/9813Liver biopsy is the gold standard method to assess nonalcoholic steatohepatitis (NASH) resolution after therapeutic interventions. We developed and validated a simple and noninvasive scoring system to predict NASH resolution without fibrosis worsening after 1 year of lifestyle intervention. This was a prospective cohort study conducted in 261 patients with histologically proven NASH who were treated with lifestyle changes for 52 weeks and underwent a second liver biopsy to confirm NASH resolution. We divided the data into development (140 subjects) and validation (121 individuals) sets. NASH resolution occurred in 28% (derivation group) and 27% (validation group). At the multivariable analysis, weight loss (odds ratio [OR] = 2.75, 95% confidence interval [CI] 1.65-4.58; P A noninvasive prediction model including weight loss, type 2 diabetes, alanine aminotransferase normalization, age, and a nonalcoholic fatty liver activity score ≥5 may be useful to identify NASH resolution in patients under lifestyle intervention. (Hepatology 2016;63:1875-1887).enAdultFemaleForecastingHumansLife StyleMaleMiddle AgedModels, TheoreticalMultivariate AnalysisNon-alcoholic Fatty Liver Diseaseresearch article2684928710.1002/hep.284841527-3350