Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.

Fernández-Martínez, MartaRuiz Del Castillo, BelénLecea-Cuello, Maria JesúsRodríguez-Baño, JesúsPascual, ÁlvaroMartínez-Martínez, LuisSpanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH)2023-01-252023-01-252017-10-03http://hdl.handle.net/10668/12423The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated. The resistance to (one or more) aminoglycosides was significantly higher in Kp-ESBL (104/139, 74.8%) than in Ec-ESBL (171/420, 40.7%; p enEscherichia coliKlebsiella pneumoniaeSpainaminoglycoside-modifying enzymesextended spectrum β-lactamasesAminoglycosidesAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, Multiple, BacterialEscherichia coliHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsPrevalenceSpainbeta-LactamasesPrevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.research article29727265open access10.1089/mdr.2017.01021931-8448PMC5946734https://europepmc.org/articles/pmc5946734?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946734/pdf