Resina, ElenaDonday, María GMartínez-Domínguez, Samuel JLaserna-Mendieta, Emilio JoséLanas, ÁngelLucendo, Alfredo JSánchez-Luengo, MartaAlcaide, NoeliaFernández-Salazar, LuisDe La Peña-Negro, LuisaBujanda, LuisArbulo, Marta Gómez-Ruiz deAlcedo, JavierPérez-Aísa, ÁngelesRodríguez, RaúlHermida, SandraBrenes, YanireNyssen, Olga PGisbert, Javier P2023-05-032023-05-032022-08-292077-0383http://hdl.handle.net/10668/21340The stool antigen test (SAT) represents an attractive alternative for detection of Helicobacter pylori. The aim of this study was to assess the accuracy of a new SAT, the automated LIAISON® Meridian H. pylori SA based on monoclonal antibodies, compared to the defined gold standard 13C-urea breath test (UBT). This prospective multicentre study (nine Spanish centres) enrolled patients ≥18 years of age with clinical indication to perform UBT for the initial diagnosis and for confirmation of bacterial eradication. Two UBT methods were used: mass spectrometry (MS) including citric acid (CA) or infrared spectrophotometry (IRS) without CA. Overall, 307 patients (145 naïve, 162 with confirmation of eradication) were analysed. Using recommended cut-off values (negative SATenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Helicobacter pyloridiagnosisstool antigen testurea breath testresearch article36079007open access10.3390/jcm11175077PMC9457298https://www.mdpi.com/2077-0383/11/17/5077/pdf?version=1661910057https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457298/pdf