Olmedo-Requena, RocíoLozano-Lorca, MacarenaSalcedo-Bellido, InmaculadaJiménez-Pacheco, AntonioVázquez-Alonso, FernandoGarcía-Caballos, MartaSánchez, María-JoséJiménez-Moleón, José-JuanJ2023-02-082023-02-082020-03-14http://hdl.handle.net/10668/15254The etiology of prostate cancer (PCa) remains largely unknown. Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) cancer prevention recommendations and its relationship to PCa was evaluated. A total of 398 incident PCa cases and 302 controls were included. The selection criteria for both cases and controls were: (i) age between 40-80 years; and (ii) residence in the coverage area of the reference hospitals for 6 months or more prior to recruitment. A score to measure the compliance with the recommendations of 2018 WCRC/AICR criteria was built. The level of compliance was used as a continuous variable and categorized in terciles. The aggressiveness of PCa was determined according to the ISUP classification. Adjusted odds ratios (aOR) and their 95% confidence intervals (95% CI) were estimated using multivariable logistic regression models. A slight protective tendency was observed between the level of compliance with the preventive recommendations and PCa risk, aOR = 0.81 (95% CI 0.69-0.96) for the total cases of PCa. This association also was observed when the aggressiveness was considered. In addition, limiting consumption of "fast foods", sugar-sweetened drinks, and alcohol were independently associated with lower risk of PCa.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/WCRF/AICR 2018 recommendationscase-control studynutrition-based guidelinesprostate cancerAcademies and InstitutesAdultAgedAged, 80 and overExerciseGuideline AdherenceHumansMaleMiddle AgedPractice Guidelines as TopicProstatic NeoplasmsUnited Statesresearch article32183345open access10.3390/nu120307682072-6643PMC7146507https://www.mdpi.com/2072-6643/12/3/768/pdf?version=1584183083https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146507/pdf