Garcia-Martinez, LucreciaGracia-Ahulfinger, IreneMachuca, IsabelCantisan, SaraDe La Fuente, SorayaNatera, ClaraPerez-Nadales, ElenaVidal, ElisaRivero, AntonioRodriguez-Lopez, FernandoDel Prado, Jose RamonTorre-Cisneros, Julian2023-01-252023-01-252016-04-20García-Martínez L, Gracia-Ahulfinger I, Machuca I, Cantisán S, De La Fuente S, Natera C, et al. Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study. J Antimicrob Chemother. 2016 Sep;71(9):2606-11http://hdl.handle.net/10668/10140There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P  A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.enAnti-bacterial agentsAttitude of health personnelBehavior therapyDrug resistance, bacterialDrug utilizationEducation, medical, continuingEnterococcus faecalisGram-positive bacterial infectionsHealth policyHospitals, universityHumansLinezolidNon-randomized controlled trials as topicRetrospective studiesStaphylococcusSurveys and questionnairesTertiary care centersresearch article27246230open accessCentros de atención terciariaEducación médica continuaEstudios retrospectivosHospitales universitariosInfecciones por bacterias grampositivasPolítica de saludUtilización de medicamentos10.1093/jac/dkw1791460-2091https://academic.oup.com/jac/article-pdf/71/9/2606/17430221/dkw179.pdf