García de Guadiana-Romualdo, LuisMorell-García, DanielRodríguez-Fraga, OlaiaMorales-Indiano, CristianMaría Lourdes Padilla Jiménez, AnaGutiérrez Revilla, José IgnacioUrrechaga, EloísaÁlamo, José MaríaHernando Holgado, Ana MaríaLorenzo-Lozano, María Del CarmenSánchez Fdez-Pacheco, Silviade la Hera Cagigal, PatriciaJuncos Tobarra, María ÁngelesVílchez, Juan AVírseda Chamorro, IsabelGutiérrez Garcia, IrenePastor Murcia, YolandaSahuquillo Frías, LauraAltimira Queral, LauraNuez-Zaragoza, ElisaAdell Ruiz de León, JuanRuiz Ripa, AliciaSalas Gómez-Pablos, PalomaCebreiros López, IriaFernández Uriarte, AmaiaLarruzea, ÁlexLópez Yepes, María LuisaSancho-Rodríguez, NataliaZamorano Andrés, María ConsueloPedregosa Díaz, JoséAcevedo Alcaraz, CristinaBlázquez Manzanera, Alfonso-LPérez Sanmartín, SoniaBaamonde Calzada, María Del CarmenVera, MarinaValera Nuñez, ElenaCanalda Campás, MagdalenaGarcía Muñoz, SaraBauça, Josep MiquelVicente Gutiérrez, LuisJiménez Añón, LauraPérez Martínez, AlfonsoPons Castillo, AurelioGonzález Tamayo, RuthFérriz Vivancos, JorgeJosé Alcaide Martín, MaríaFerrer Díaz de Brito Fernández, VicenteAguadero, VicenteGarcía Arévalo, María GloriaArnaldos Carrillo, MaríaGonzález Morales, MercedesNúñez Gárate, MaríaRuiz Iruela, CristinaEsteban Torrella, PatriciaVila Pérez, MartíEgea-Caparrós, Jose ManuelSáenz, LuisGalán Ortega, AmparoConsuegra-Sánchez, Luciano2023-02-092023-02-092021-03-15http://hdl.handle.net/10668/17269Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P  In this multicentre study, myocardial injury was a common finding in COVID-19 patients. Its prevalence increased when a sex-specific cut-off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30-day mortality, irrespective of cardiac troponin assay and cut-offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID-19.enCOVID-19SARS-CoV-2cardiac troponin Icardiac troponin Tmyocardial injuryprognosisAgedAged, 80 and overCOVID-19CardiomyopathiesFemaleHumansMaleMiddle AgedMortalityOdds RatioPrognosisRetrospective StudiesSARS-CoV-2Severity of Illness IndexTroponin ITroponin Tresearch article33660278open access10.1111/eci.135321365-2362PMC7995181https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995181https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995181/pdf