Rosado-Sanchez, I.Herrero-Fernandez, I.Alvarez-Rios, A. I.Genebat, M.Abad-Carrillo, M. A.Ruiz-Mateos, E.Pulido, F.Gonzalez-Garcia, J.Montero, M.Bernal-Morell, E.Vidal, F.Leal, M.Pacheco, Y. M.2023-02-122023-02-122017-07-25Rosado-Sánchez I, Herrero-Fernández I, Álvarez-Ríos AI, Genebat M, Abad-Carrillo MA, Ruiz-Mateos E, et al . A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00605-17.0066-4804http://hdl.handle.net/10668/19000We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.enCD4/CD8 T-cell ratiodelayed cARTlow CD4 recoveryT-cell turnoverthymic functionCD4/CD8 ratioantiretroviral therapyhuman immunodeficiency virusimmunodiscordantImmunodeficiency-virus type-1Cd4 recoveryTropismTurnoverEventsSwitchNaiveCartRiskT-Lymphocytes, RegulatoryHIV InfectionsCD4 Lymphocyte CountBiomarkersCD8-Positive T-Lymphocytesresearch articleRestricted AccessLinfocitos TVIHRecuento de linfocito CD4Linfocitos T reguladoresBiomarcadoresTerapéutica10.1128/AAC.00605-171098-6596https://europepmc.org/articles/pmc5527653?pdf=render406259400060