Carbonell, RaquelUrgelés, SilviaSalgado, MelinaRodríguez, AlejandroReyes, Luis FelipeFuentes, Yuli VSerrano, Cristian CCaceres, Eder LBodí, MaríaMartín-Loeches, IgnacioSolé-Violán, JordiDíaz, EmiliGómez, JosepTrefler, SandraVallverdú, MontserratMurcia, JosefaAlbaya, AntonioLoza, AnaSocias, LorenzoBallesteros, Juan CarlosPapiol, ElisabethViña, LucíaSancho, SusanaNieto, MercedesDel, MLorente, CarmenBadallo, OihaneFraile, VirginiaArméstar, FernandoEstella, AngelAbanses, PaulaSancho, IsabelGuasch, NeusMoreno, GerardCOVID-19 SEMICYUC Working Group and the LIVEN-Covid-19 Investigators2023-05-032023-05-032022-06-30http://hdl.handle.net/10668/22321Procalcitonin (PCT) and C-Reactive Protein (CRP) are useful biomarkers to differentiate bacterial from viral or fungal infections, although the association between them and co-infection or mortality in COVID-19 remains unclear. The study represents a retrospective cohort study of patients admitted for COVID-19 pneumonia to 84 ICUs from ten countries between (March 2020-January 2021). Primary outcome was to determine whether PCT or CRP at admission could predict community-acquired bacterial respiratory co-infection (BC) and its added clinical value by determining the best discriminating cut-off values. Secondary outcome was to investigate its association with mortality. To evaluate the main outcome, a binary logistic regression was performed. The area under the curve evaluated diagnostic performance for BC prediction. 4635 patients were included, 7.6% fulfilled BC diagnosis. PCT (0.25[IQR 0.1-0.7] versus 0.20[IQR 0.1-0.5]ng/mL, p These biomarkers at ICU admission led to a poor ability to predict BC among patients with COVID-19 pneumonia. Baseline values of PCTenBacterial co-infectionC-reactive proteinCovid-19 pneumoniaMortalityProcalcitoninBacterial InfectionsBiomarkersC-Reactive ProteinCOVID-19CoinfectionHumansPredictive Value of TestsProcalcitoninROC CurveRespiratory Tract InfectionsRetrospective Studiesresearch article35781017open access10.1016/j.jinf.2022.06.0241532-2742PMC9245395https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245395https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245395/pdf