Jurado, José MiguelZarcos, IreneDelgado, MayteBlancas, IsabelLegerén, MartaGarcía-Puche, José Luis2015-04-302015-04-302013-04Jurado JM, Zarcos I, Delgado M, Blancas I, Legerén M, García-Puche JL. Temsirolimus in overtreated metastatic renal cancer with subsequent use of sunitinib: A case report. Oncol Lett. 2013 Apr; 5(4):1382-13841792-1074http://hdl.handle.net/10668/1885JOURNAL ARTICLEDuring the last decade, we have been developing new therapeutic strategies for the treatment of renal cancer, based on knowledge derived from molecular biology. We report a case of long-term renal metastatic cancer progression despite therapy with sunitinib and interleukin, which are the most active drugs in renal cancer. Disease stabilization for 58 weeks was achieved upon sequential use of temsirolimus, following the occurrence of disease progression during angiogenic therapy. The patient demonstrated excellent tolerance without marked symptoms for 10 months. Hypothyroidism and mumps-related adverse events were present. The survival time from diagnosis to lung metastasis was 8 years. Thus, this case demonstrates promising therapeutic effects of the sequential use of tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors during different stages of the disease.enTemsirolimusmThor inhibitorsMetastatic renalCarcinomaMatástasisCarcinoma renalInhibidores de la angiogénesisTomografía computarizada por rayos XRelación dosis-respuesta a drogaHipercolesterolemiaHipertrigliceridemiaHipotiroidismoNeoplasias renalesLeucopeniaMasculinosAdultoAnemiaAntiinflamatoriosFiebreMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Growth Inhibitors::Angiogenesis InhibitorsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, X-Ray ComputedMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, DrugMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Radioisotope::Radionuclide Imaging::Tomography, Emission-ComputedMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Temperature Changes::FeverMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::HypercholesterolemiaMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::HypertriglyceridemiaMedical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases::HypothyroidismMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Kidney NeoplasmsMedical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::LeukopeniaMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung DiseasesMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Urogenital Surgical Procedures::Urologic Surgical Procedures::NephrectomyMedical Subject Headings::Diseases::Respiratory Tract Diseases::Pleural Diseases::Pleural EffusionMedical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::AnemiaMedical Subject Headings::Named Groups::Persons::Age Groups::AdultMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::ThyrotropinMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::ThyroxineMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agentsresearch article23599798open access10.3892/ol.2013.11841792-1082 (on-line)PMC3629020