Fernandez-Martinez, Nicolas FranciscoOrtiz-Gonzalez-Serna, RocioSerrano-Ortiz, AlvaroRivera-Izquierdo, MarioRuiz-Montero, RafaelPerez-Contreras, MarinaGuerrero-Fernandez de Alba, InmaculadaRomero-Duarte, AlvaroSalcedo-Leal, Inmaculada2023-02-092023-02-092021-08-17Fernández-Martínez NF, Ortiz-González-Serna R, Serrano-Ortiz Á, Rivera-Izquierdo M, Ruiz-Montero R, Pérez-Contreras M, et al. Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study. Int J Environ Res Public Health. 2021 Aug 26;18(17):9018http://hdl.handle.net/10668/18508Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan-Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2Hospital mortalityRisk factorsSexAgedCOVID-19FemaleHospital mortalityHospitalizationHumansLongitudinal studiesMalePandemicsRetrospective studiesRisk factorsSARS-CoV-2Sex characteristicsresearch article34501608open accessCaracteres sexualesEstudios retrospectivosHospitalizaciónMortalidad hospitalariaPandemias10.3390/ijerph181790181660-4601PMC8431708https://www.mdpi.com/1660-4601/18/17/9018/pdf?version=1630314285https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431708/pdf