Serrano-Castro, Pedro JGarzon-Maldonado, Francisco JCasado-Naranjo, IgnacioOllero-Ortiz, AngelaMínguez-Castellanos, AdolfoIglesias-Espinosa, MarBaena-Palomino, PabloSanchez-Sanchez, VioletaSanchez-Perez, Rosa MariaRubi-Callejon, JoseEstevez-Maria, Jose CarlosGaleano-Bilbao, BenitoRomero-Imbroda, JesusSobrino, BeatrizArrabal-Gomez, CarlosOliver-Martos, BegoñaMuñoz-Becerra, LuisRequena, NereaGonzalez Alvarez de Sotomayor, Maria Del MarEstivill-Torrus, GuillermoSuarez, JuanCiano-Petersen, Nicolas LundahlPons-Pons, GraciaReyes-Bueno, Jose AntonioCabezudo-Garcia, PabloAguilar-Castillo, Maria JoséDe la Cruz Cosme, CarlosDuque-Holguera, MariaCuartero-Rodriguez, EvaVilches-Carrillo, Rosa MaríaCarrera-Muñoz, IsmaelCarnero-Pardo, CristóbalRamirez-Garcia, TeresaOropesa, Juan ManuelDominguez-Mayoral, AnaPelaez-Viñas, NazaretValiente, Luciade Fonseca, Fernando Rodríguez2023-05-032023-05-032022-02-21Serrano-Castro PJ, Garzón-Maldonado FJ, Casado-Naranjo I, Ollero-Ortiz A, Mínguez-Castellanos A, Iglesias-Espinosa M, et al. The cognitive and psychiatric subacute impairment in severe Covid-19. Sci Rep. 2022 Mar 3;12(1):3563.http://hdl.handle.net/10668/19593Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Central nervous system infectionsCognitive neuroscienceDiseases of the nervous systemDementiaNeurodegenerative diseasesNeuroimmunologyCOVID-19Cognition DisordersHumansMental DisordersSARS-CoV-2Severity of Illness Indexresearch article35241761open accessHumanosSARS-CoV-2Trastornos mentalesTrastornos del conocimientoÍndice de severidad de la enfermedad10.1038/s41598-022-07559-92045-2322PMC8894467https://www.nature.com/articles/s41598-022-07559-9.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894467/pdf