Moya-García, Aurelio A.Pino-Ángeles, AlmudenaSánchez-Jiménez, FranciscaUrdiales, José LuisMedina, Miguel Ángel2022-09-212022-09-212021-03-11Moya-García AA, Pino-Ángeles A, Sánchez-Jiménez F, Urdiales JL, Medina MÁ. Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach. Biomolecules. 2021 Mar 11;11(3):415.http://hdl.handle.net/10668/4090Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four different G-protein coupled receptors, which expression and signalling pathways are tissue-specific. Histamine metabolism conforms a very complex network that connect many metabolic processes important for homeostasis, including nitrogen and energy metabolism. This review brings together and analyses the current information on the relationships of the "histamine system" with other important metabolic modules in human physiology, aiming to bridge current information gaps. In this regard, the molecular characterization of the role of histamine in the modulation of angiogenesis-mediated processes, such as cancer, makes a promising research field for future biomedical advances.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Metabolic remodellingAngiogenesisSystems biologyHistamineCancerMetabolismBiología de sistemasHistaminaNeoplasiasHomeostasisMetabolismoMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::Regulatory Sequences, Nucleic Acid::Gene Regulatory NetworksMedical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::HistamineMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter::Receptors, Biogenic Amine::Receptors, HistamineMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal TransductionMedical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Cardiovascular Physiological Processes::Neovascularization, PhysiologicMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Systems BiologyMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-CoupledMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::HomeostasisMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction::Synaptic TransmissionMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy MetabolismMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunityreview article33799732open access10.3390/biom110304152218-273XPMC8000605